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Pptc7 PTC7 protein phosphatase homolog [ Mus musculus (house mouse) ]

Gene ID: 320717, updated on 9-Mar-2023

Summary

Official Symbol
Pptc7provided by MGI
Official Full Name
PTC7 protein phosphatase homologprovided by MGI
Primary source
MGI:MGI:2444593
See related
Ensembl:ENSMUSG00000038582 AllianceGenome:MGI:2444593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TA-PP2C; 9130017A15Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in peptidyl-serine dephosphorylation and regulation of ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; connective tissue; genitourinary system; and gut. Orthologous to human PPTC7 (protein phosphatase targeting COQ7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 24.7), adrenal adult (RPKM 19.6) and 28 other tissues See more
Orthologs
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Genomic context

See Pptc7 in Genome Data Viewer
Location:
5; 5 F
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122422461..122462344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122284398..122324281)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene tectonic family member 1 Neighboring gene RIKEN cDNA 1700112N08 gene Neighboring gene RAD9 checkpoint clamp component B Neighboring gene VPS29 retromer complex component Neighboring gene family with sequence similarity 216, member A Neighboring gene predicted gene, 32853 Neighboring gene GPN-loop GTPase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in peptidyl-serine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein phosphatase PTC7 homolog
Names
T-cell activation protein phosphatase 2C
NP_796216.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177242.4NP_796216.2  protein phosphatase PTC7 homolog

    See identical proteins and their annotated locations for NP_796216.2

    Status: PROVISIONAL

    Source sequence(s)
    AC093473, AC127266
    Consensus CDS
    CCDS39255.1
    UniProtKB/Swiss-Prot
    Q6NVE9, Q8BVC7
    Related
    ENSMUSP00000051838.9, ENSMUST00000053426.15
    Conserved Domains (1) summary
    cl00120
    Location:66302
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122422461..122462344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)