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Dnai7 dynein axonemal intermediate chain 7 [ Mus musculus (house mouse) ]

Gene ID: 320662, updated on 5-Mar-2024

Summary

Official Symbol
Dnai7provided by MGI
Official Full Name
dynein axonemal intermediate chain 7provided by MGI
Primary source
MGI:MGI:2444480
See related
Ensembl:ENSMUSG00000043541 AllianceGenome:MGI:2444480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Las1; Casc1; Cfap94; A230084G12Rik
Summary
Enables beta-tubulin binding activity and microtubule binding activity. Predicted to act upstream of or within microtubule sliding. Located in cilium; cytoplasm; and microtubule cytoskeleton. Part of axonemal dynein complex. Orthologous to human DNAI7 (dynein axonemal intermediate chain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.2), spleen adult (RPKM 4.7) and 9 other tissues See more
Orthologs
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Genomic context

See Dnai7 in Genome Data Viewer
Location:
6 G3; 6 77.37 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145120556..145156866, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145174833..145211017, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene branched chain aminotransferase 1, cytosolic Neighboring gene predicted gene, 26666 Neighboring gene STARR-seq mESC enhancer starr_17771 Neighboring gene STARR-positive B cell enhancer ABC_E11339 Neighboring gene STARR-seq mESC enhancer starr_17772 Neighboring gene predicted gene, 38925 Neighboring gene STARR-positive B cell enhancer ABC_E8147 Neighboring gene STARR-seq mESC enhancer starr_17775 Neighboring gene STARR-seq mESC enhancer starr_17776 Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene predicted gene 15543 Neighboring gene STARR-seq mESC enhancer starr_17780 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene Kirsten rat sarcoma viral oncogene homolog Neighboring gene predicted gene 15706 Neighboring gene ribosomal protein S25, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within microtubule sliding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of axonemal dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
part_of inner dynein arm ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynein axonemal intermediate chain 7
Names
cancer susceptibility candidate 1
cancer susceptibility candidate gene 1 protein homolog
cancer susceptibility candidate protein 1
cilia and flagella associated protein 94
dynein intermediate chain CFAP94, axonemal
lung adenoma susceptibility 1
lung adenoma susceptibility protein 1
protein CASC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177222.4NP_796196.3  dynein axonemal intermediate chain 7

    See identical proteins and their annotated locations for NP_796196.3

    Status: VALIDATED

    Source sequence(s)
    AY485608, BB374869, CJ202396
    Consensus CDS
    CCDS39705.1
    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    UniProtKB/TrEMBL
    A0A0R4J0S9
    Related
    ENSMUSP00000062279.8, ENSMUST00000060797.10
    Conserved Domains (2) summary
    pfam12366
    Location:244469
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:39229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    145120556..145156866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506971.3XP_006507034.1  dynein axonemal intermediate chain 7 isoform X5

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (1) summary
    pfam15927
    Location:39183
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  2. XM_017321645.2XP_017177134.1  dynein axonemal intermediate chain 7 isoform X10

    Conserved Domains (2) summary
    pfam12366
    Location:336483
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:39205
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  3. XM_011241588.2XP_011239890.1  dynein axonemal intermediate chain 7 isoform X1

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (1) summary
    pfam15927
    Location:39218
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  4. XM_006506974.3XP_006507037.1  dynein axonemal intermediate chain 7 isoform X8

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (2) summary
    pfam12366
    Location:377524
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:39229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  5. XM_006506972.3XP_006507035.1  dynein axonemal intermediate chain 7 isoform X6

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (2) summary
    pfam12366
    Location:429576
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:39229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  6. XM_011241593.2XP_011239895.1  dynein axonemal intermediate chain 7 isoform X4

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (2) summary
    pfam12366
    Location:440587
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:39229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  7. XM_006506970.3XP_006507033.1  dynein axonemal intermediate chain 7 isoform X3

    UniProtKB/TrEMBL
    A0A0R4J1G3
    Related
    ENSMUSP00000107357.2, ENSMUST00000111728.8
    Conserved Domains (1) summary
    pfam15927
    Location:39229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  8. XM_006506973.3XP_006507036.1  dynein axonemal intermediate chain 7 isoform X7

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (2) summary
    pfam12366
    Location:391538
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:6137
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  9. XM_017321646.2XP_017177135.1  dynein axonemal intermediate chain 7 isoform X9

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (2) summary
    pfam12366
    Location:366513
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:1112
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  10. XM_011241590.1XP_011239892.1  dynein axonemal intermediate chain 7 isoform X2

    See identical proteins and their annotated locations for XP_011239892.1

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (1) summary
    pfam15927
    Location:26216
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  11. XM_011241591.1XP_011239893.1  dynein axonemal intermediate chain 7 isoform X2

    See identical proteins and their annotated locations for XP_011239893.1

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (1) summary
    pfam15927
    Location:26216
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  12. XM_011241592.1XP_011239894.1  dynein axonemal intermediate chain 7 isoform X2

    See identical proteins and their annotated locations for XP_011239894.1

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (1) summary
    pfam15927
    Location:26216
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  13. XM_011241589.3XP_011239891.1  dynein axonemal intermediate chain 7 isoform X2

    See identical proteins and their annotated locations for XP_011239891.1

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (1) summary
    pfam15927
    Location:26216
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  14. XM_036166231.1XP_036022124.1  dynein axonemal intermediate chain 7 isoform X9

    UniProtKB/Swiss-Prot
    Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
    Conserved Domains (2) summary
    pfam12366
    Location:366513
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:1112
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  15. XM_011241594.2XP_011239896.1  dynein axonemal intermediate chain 7 isoform X11

    Conserved Domains (1) summary
    pfam15927
    Location:39229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  16. XM_006506978.3XP_006507041.1  dynein axonemal intermediate chain 7 isoform X12

    Conserved Domains (1) summary
    pfam15927
    Location:39229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  17. XM_030255463.2XP_030111323.1  dynein axonemal intermediate chain 7 isoform X13

    Conserved Domains (1) summary
    pfam15927
    Location:26216
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

RNA

  1. XR_001785141.3 RNA Sequence

    Related
    ENSMUST00000111727.8
  2. XR_001785140.2 RNA Sequence

  3. XR_378098.3 RNA Sequence