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Dnai7 dynein axonemal intermediate chain 7 [ Mus musculus (house mouse) ]

Gene ID: 320662, updated on 17-Jan-2023

Summary

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Official Symbol
Dnai7provided by MGI
Official Full Name
dynein axonemal intermediate chain 7provided by MGI
Primary source
MGI:MGI:2444480
See related
Ensembl:ENSMUSG00000043541 AllianceGenome:MGI:2444480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Las1; Casc1; Cfap94; A230084G12Rik
Summary
Enables beta-tubulin binding activity and microtubule binding activity. Predicted to act upstream of or within microtubule sliding. Located in cilium; cytoplasm; and microtubule cytoskeleton. Part of axonemal dynein complex. Orthologous to human DNAI7 (dynein axonemal intermediate chain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.2), spleen adult (RPKM 4.7) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Dnai7 in Genome Data Viewer
Location:
6 G3; 6 77.37 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145120556..145156866, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145174833..145211017, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene branched chain aminotransferase 1, cytosolic Neighboring gene predicted gene, 26666 Neighboring gene predicted gene, 38925 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene predicted gene 15543 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene Kirsten rat sarcoma viral oncogene homolog Neighboring gene predicted gene 15706

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding. Wirschell M, et al. Mol Biol Cell, 2009 Jul. PMID 19420136, Free PMC Article
  2. Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. Liu Y, et al. Cancer Res, 2007 Nov 1. PMID 17974961
  3. Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines. Galbiati F, et al. Cancer Lett, 2006 Dec 8. PMID 16458428
  4. A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice. Nathan BM, et al. Endocrinology, 2006 Nov. PMID 16873534
  5. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Zhang Z, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14583591, Free PMC Article

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The differential degradation of Las1-A/J and Las-B6 produced from the 2 corresponding alleles, has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis.
    Title: Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression.
  2. Las1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms and AA changes in lung tumor susceptibility. It may be a tumor suppressor.
    Title: Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
  3. Casc1 knockout mouse tumor bioassays showed that Casc1-deficient mice were susceptible to chemical induction of lung tumors.
    Title: Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.
  4. Whole-genome association analyis of lung tumor susceptibility refined the Pas1 locus to a region of less than 0.5 Mb containing two strong candidates, Kras2 and Casc1 (also known as Las1).
    Title: Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within microtubule sliding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of axonemal dynein complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of inner dynein arm ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dynein axonemal intermediate chain 7; protein CASC1
Names
cancer susceptibility candidate 1
cancer susceptibility candidate gene 1 protein homolog
cancer susceptibility candidate protein 1
cilia and flagella associated protein 94
dynein intermediate chain CFAP94, axonemal
lung adenoma susceptibility 1
lung adenoma susceptibility protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177222.4 → NP_796196.3  dynein axonemal intermediate chain 7

    See identical proteins and their annotated locations for NP_796196.3

    Status: VALIDATED

    Source sequence(s)
    AY485608, BB374869, CJ202396
    Consensus CDS
    CCDS39705.1
    UniProtKB/Swiss-Prot
    Q6TDU8
    UniProtKB/TrEMBL
    A0A0R4J0S9
    Related
    ENSMUSP00000062279.8, ENSMUST00000060797.10
    Conserved Domains (2) summary
    pfam12366
    Location:244 → 469
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:39 → 229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    145120556..145156866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506971.3 → XP_006507034.1  protein CASC1 isoform X5

    Conserved Domains (1) summary
    pfam15927
    Location:39 → 183
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  2. XM_017321645.2 → XP_017177134.1  protein CASC1 isoform X10

    Conserved Domains (2) summary
    pfam12366
    Location:336 → 483
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:39 → 205
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  3. XM_011241588.2 → XP_011239890.1  protein CASC1 isoform X1

    Conserved Domains (1) summary
    pfam15927
    Location:39 → 218
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  4. XM_006506974.3 → XP_006507037.1  protein CASC1 isoform X8

    Conserved Domains (2) summary
    pfam12366
    Location:377 → 524
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:39 → 229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  5. XM_006506972.3 → XP_006507035.1  protein CASC1 isoform X6

    Conserved Domains (2) summary
    pfam12366
    Location:429 → 576
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:39 → 229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  6. XM_011241593.2 → XP_011239895.1  protein CASC1 isoform X4

    Conserved Domains (2) summary
    pfam12366
    Location:440 → 587
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:39 → 229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  7. XM_006506970.3 → XP_006507033.1  protein CASC1 isoform X3

    Related
    ENSMUSP00000107357.2, ENSMUST00000111728.8
    Conserved Domains (1) summary
    pfam15927
    Location:39 → 229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  8. XM_006506973.3 → XP_006507036.1  protein CASC1 isoform X7

    Conserved Domains (2) summary
    pfam12366
    Location:391 → 538
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:6 → 137
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  9. XM_017321646.2 → XP_017177135.1  protein CASC1 isoform X9

    Conserved Domains (2) summary
    pfam12366
    Location:366 → 513
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:1 → 112
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  10. XM_011241590.1 → XP_011239892.1  protein CASC1 isoform X2

    See identical proteins and their annotated locations for XP_011239892.1

    Conserved Domains (1) summary
    pfam15927
    Location:26 → 216
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  11. XM_011241591.1 → XP_011239893.1  protein CASC1 isoform X2

    See identical proteins and their annotated locations for XP_011239893.1

    Conserved Domains (1) summary
    pfam15927
    Location:26 → 216
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  12. XM_011241592.1 → XP_011239894.1  protein CASC1 isoform X2

    See identical proteins and their annotated locations for XP_011239894.1

    Conserved Domains (1) summary
    pfam15927
    Location:26 → 216
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  13. XM_011241589.3 → XP_011239891.1  protein CASC1 isoform X2

    See identical proteins and their annotated locations for XP_011239891.1

    Conserved Domains (1) summary
    pfam15927
    Location:26 → 216
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  14. XM_036166231.1 → XP_036022124.1  protein CASC1 isoform X9

    Conserved Domains (2) summary
    pfam12366
    Location:366 → 513
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:1 → 112
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  15. XM_011241594.2 → XP_011239896.1  protein CASC1 isoform X11

    Conserved Domains (1) summary
    pfam15927
    Location:39 → 229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  16. XM_006506978.3 → XP_006507041.1  protein CASC1 isoform X12

    Conserved Domains (1) summary
    pfam15927
    Location:39 → 229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  17. XM_030255463.2 → XP_030111323.1  protein CASC1 isoform X13

    Conserved Domains (1) summary
    pfam15927
    Location:26 → 216
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

RNA

  1. XR_001785141.3 RNA Sequence

    Related
    ENSMUST00000111727.8

  2. XR_001785140.2 RNA Sequence

  3. XR_378098.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TDU8.1 GenPept UniProtKB/Swiss-Prot:Q6TDU8

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