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Antdh Antennal dehydrogenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32058, updated on 4-Jan-2025

Summary

Official Symbol
Antdhprovided by FlyBase
Official Full Name
Antennal dehydrogenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0026268
Locus tag
Dmel_CG1386
See related
AllianceGenome:FB:FBgn0026268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
antdh; AntDH; CG1386; Dmel\CG1386; FOHSDR
Summary
Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be located in cytoplasm. Is expressed in adult head and third segment of antenna. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Antdh in Genome Data Viewer
Location:
10A10-10A10; 1-33 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11168030..11169058, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11062063..11063091, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene l(3)mbt interacting protein 1 Neighboring gene retroactive Neighboring gene Dynein light intermediate chain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables 17-beta-ketosteroid reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables 3-keto sterol reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables oxidoreductase activity ISM
Inferred from Sequence Model
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
PubMed 

General protein information

Preferred Names
antennal dehydrogenase
Names
Antdh-PA
CG1386-PA
antdh
NP_572695.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11168030..11169058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132467.3NP_572695.2  antennal dehydrogenase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572695.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SY92, Q9VZ19
    Related
    FBpp0073324
    Conserved Domains (2) summary
    COG4221
    Location:1250
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
    cl21454
    Location:1245
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins