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Dennd5b DENN domain containing 5B [ Mus musculus (house mouse) ]

Gene ID: 320560, updated on 22-Jan-2023

Summary

Official Symbol
Dennd5bprovided by MGI
Official Full Name
DENN domain containing 5Bprovided by MGI
Primary source
MGI:MGI:2444273
See related
Ensembl:ENSMUSG00000030313 AllianceGenome:MGI:2444273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm17524; 9330160C06Rik; D030011O10Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of triglyceride transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human DENND5B (DENN domain containing 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 4.7), cerebellum adult (RPKM 4.0) and 26 other tissues See more
Orthologs
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Genomic context

See Dennd5b in Genome Data Viewer
Location:
6; 6 G3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148889566..149003178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148988069..149101680, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3010003L21 gene Neighboring gene ES cell cis-regulatory motif 1b Neighboring gene predicted gene, 25539 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene predicted gene 15781 Neighboring gene predicted gene, 22578 Neighboring gene SEH1-like (S. cerevisiae pseudogene Neighboring gene predicted gene, 23462 Neighboring gene electron transfer flavoprotein beta subunit lysine methyltransferase Neighboring gene antagonist of mitotic exit network 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of triglyceride transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DENN domain-containing protein 5B
Names
DENN/MADD domain containing 5B
RAB6IP1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177192.3NP_796166.2  DENN domain-containing protein 5B

    See identical proteins and their annotated locations for NP_796166.2

    Status: VALIDATED

    Source sequence(s)
    AC140327, AK135015, BB656426, BC132535, CN537548, CV558497
    Consensus CDS
    CCDS20714.2
    UniProtKB/Swiss-Prot
    A2RSQ0, Q8BWK2
    Related
    ENSMUSP00000107182.2, ENSMUST00000111557.8
    Conserved Domains (6) summary
    smart00801
    Location:499574
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:19120
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:9361044
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:187375
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:780924
    RUN; RUN domain
    cl02689
    Location:11271264
    RUN; RUN domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    148889566..149003178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507063.5XP_006507126.1  DENN domain-containing protein 5B isoform X1

    Conserved Domains (6) summary
    smart00801
    Location:521596
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:19142
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:9581066
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:209397
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:802946
    RUN; RUN domain
    cl02689
    Location:11491286
    RUN; RUN domain
  2. XM_017321643.2XP_017177132.1  DENN domain-containing protein 5B isoform X2

    Conserved Domains (6) summary
    smart00801
    Location:421496
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:142
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:858966
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:109297
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:702846
    RUN; RUN domain
    cl02689
    Location:10491186
    RUN; RUN domain
  3. XM_036166229.1XP_036022122.1  DENN domain-containing protein 5B isoform X3

    Conserved Domains (5) summary
    smart00801
    Location:193268
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:630738
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02759
    Location:474618
    RUN; RUN domain
    cl02689
    Location:821958
    RUN; RUN domain
    cl11519
    Location:169
    DENN; DENN (AEX-3) domain
  4. XM_030255459.2XP_030111319.1  DENN domain-containing protein 5B isoform X3

    Conserved Domains (5) summary
    smart00801
    Location:193268
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:630738
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02759
    Location:474618
    RUN; RUN domain
    cl02689
    Location:821958
    RUN; RUN domain
    cl11519
    Location:169
    DENN; DENN (AEX-3) domain
  5. XM_036166230.1XP_036022123.1  DENN domain-containing protein 5B isoform X4

    Conserved Domains (4) summary
    smart00801
    Location:77152
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:514622
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02759
    Location:358502
    RUN; RUN domain
    cl02689
    Location:705842
    RUN; RUN domain