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Heatr5b HEAT repeat containing 5B [ Mus musculus (house mouse) ]

Gene ID: 320473, updated on 5-Mar-2024

Summary

Official Symbol
Heatr5bprovided by MGI
Official Full Name
HEAT repeat containing 5Bprovided by MGI
Primary source
MGI:MGI:2444098
See related
Ensembl:ENSMUSG00000039414 AllianceGenome:MGI:2444098
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1414; 2010013B10Rik; A230048G03Rik; D330050P16Rik
Summary
Predicted to be involved in endocytosis; protein localization; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within protein transport. Predicted to be located in cytoplasmic vesicle. Predicted to be active in endocytic vesicle. Orthologous to human HEATR5B (HEAT repeat containing 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 7.6), whole brain E14.5 (RPKM 7.2) and 28 other tissues See more
Orthologs
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Genomic context

See Heatr5b in Genome Data Viewer
Location:
17 E3; 17 49.54 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79060335..79142810, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78752906..78835381, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene striatin, calmodulin binding protein Neighboring gene STARR-positive B cell enhancer ABC_E1201 Neighboring gene ubiquitin-conjugating enzyme E2C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E773 Neighboring gene G patch domain containing 11 Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • KIAA1414, MGC77977

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
HEAT repeat-containing protein 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081179.1NP_001074648.1  HEAT repeat-containing protein 5B

    See identical proteins and their annotated locations for NP_001074648.1

    Status: PROVISIONAL

    Source sequence(s)
    AC151264, AC151284
    Consensus CDS
    CCDS37697.1
    UniProtKB/Swiss-Prot
    Q3TPS4, Q5DTY0, Q5PRF1, Q8C547, Q8C6W1, Q8C773
    Related
    ENSMUSP00000094882.3, ENSMUST00000097281.4
    Conserved Domains (1) summary
    sd00044
    Location:852882
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    79060335..79142810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028084.1: Suppressed sequence

    Description
    NM_028084.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
  2. NM_177168.2: Suppressed sequence

    Description
    NM_177168.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
  3. NM_177332.2: Suppressed sequence

    Description
    NM_177332.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.