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Ppm1e protein phosphatase 1E (PP2C domain containing) [ Mus musculus (house mouse) ]

Gene ID: 320472, updated on 5-Aug-2018

Summary

Official Symbol
Ppm1eprovided by MGI
Official Full Name
protein phosphatase 1E (PP2C domain containing)provided by MGI
Primary source
MGI:MGI:2444096
See related
Ensembl:ENSMUSG00000046442 Vega:OTTMUSG00000001239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
POPX1; PP2CH; AW049266; mKIAA1072; B930008A12Rik
Expression
Biased expression in frontal lobe adult (RPKM 37.0), CNS E18 (RPKM 18.9) and 7 other tissues See more
Orthologs

Genomic context

See Ppm1e in Genome Data Viewer
Location:
11; 11 C
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (87226906..87358994, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (87040408..87172496, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene proline rich 11 Neighboring gene microRNA 301 Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene tripartite motif-containing 37 Neighboring gene predicted gene, 33937 Neighboring gene RAD51 paralog C Neighboring gene testis expressed gene 14 Neighboring gene U1a1 small nuclear RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
cation binding IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein phosphatase 1E
Names
ca(2+)/calmodulin-dependent protein kinase phosphatase N
caMKN
caMKP-N
caMKP-nucleus
partner of PIX 1
partner of PIX-alpha
partner of PIXA
NP_796141.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177167.4NP_796141.2  protein phosphatase 1E

    See identical proteins and their annotated locations for NP_796141.2

    Status: VALIDATED

    Source sequence(s)
    AL596130
    Consensus CDS
    CCDS25211.1
    UniProtKB/Swiss-Prot
    Q80TL0
    UniProtKB/TrEMBL
    B2KGP3
    Related
    ENSMUSP00000061278.4, OTTMUSP00000001216, ENSMUST00000055438.4, OTTMUST00000002470
    Conserved Domains (1) summary
    cd00143
    Location:227485
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    87226906..87358994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 NOD/ShiLtJ

Genomic

  1. NT_187003.1 Reference GRCm38.p4 NOD/ShiLtJ

    Range
    357087..489251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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