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Hsp60A Heat shock protein 60A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32045, updated on 8-Oct-2018

Summary

Official Symbol
Hsp60Aprovided by FlyBase
Official Full Name
Heat shock protein 60Aprovided by FlyBase
Primary source
FLYBASE:FBgn0015245
Locus tag
Dmel_CG12101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12; BP5; CG12101; cpn60; Cpn60; d-hsp60; Dm10A; Dmel\CG12101; Dmhsp60; DmHsp60; G62; Hsp 60; hsp60; Hsp60; HSP60; hsp60A; HSP60A; Hsp64; IEF16; l(1)10Ac; l(1)BP5; l(1)dp025; l(1)G8; l(1)HM21; l(1)L12; Mmp-P1; SSP 7506

Genomic context

See Hsp60A in Genome Data Viewer
Location:
10A4-10A4; 1-33 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11108482..11112308)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11002515..11006341)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 3

Genomic regions, transcripts, and products

Bibliography

Pathways from BioSystems

  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Hsp60A gene: The Hsp60A gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
'de novo' protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
'de novo' protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic mitochondrial changes IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein refolding IEA
Inferred from Electronic Annotation
more info
 
protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heat shock protein 60A
Names
60-kDa heat shock protein, mitochondrial
CG12101-PA
CG12101-PB
Hsp 60
Hsp60A-PA
Hsp60A-PB
heat shock protein 60
heat shock protein 60 kDa
lethal(1)10Ac
mitochondrial matrix protein P1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11108482..11112308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078560.3NP_511115.2  heat shock protein 60A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511115.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02649
    UniProtKB/TrEMBL
    C7LA94
    Related
    FBpp0073290, FBtr0073434
    Conserved Domains (2) summary
    PTZ00114
    Location:12549
    PTZ00114; Heat shock protein 60; Provisional
    cd03344
    Location:24544
    GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
  2. NM_167266.1NP_727489.1  heat shock protein 60A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727489.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02649
    UniProtKB/TrEMBL
    C7LA94
    Related
    FBpp0073291, FBtr0073435
    Conserved Domains (2) summary
    PTZ00114
    Location:12549
    PTZ00114; Heat shock protein 60; Provisional
    cd03344
    Location:24544
    GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
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