U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gchfr GTP cyclohydrolase I feedback regulator [ Mus musculus (house mouse) ]

Gene ID: 320415, updated on 2-May-2024

Summary

Official Symbol
Gchfrprovided by MGI
Official Full Name
GTP cyclohydrolase I feedback regulatorprovided by MGI
Primary source
MGI:MGI:2443977
See related
Ensembl:ENSMUSG00000046814 AllianceGenome:MGI:2443977
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P35; GFRP; 2010323F13Rik
Summary
Predicted to enable several functions, including GTP cyclohydrolase binding activity; GTP-dependent protein binding activity; and amino acid binding activity. Predicted to be involved in negative regulation of GTP cyclohydrolase I activity and protein-containing complex assembly. Predicted to be located in dendrite; melanosome; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in medulla oblongata basal plate marginal layer; midbrain mantle layer; and pons marginal layer. Orthologous to human GCHFR (GTP cyclohydrolase I feedback regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 229.2), kidney adult (RPKM 48.3) and 10 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Gchfr in Genome Data Viewer
Location:
2 E5; 2 59.97 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118998269..119002870)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119167788..119172389)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAD51 recombinase Neighboring gene regulator of microtubule dynamics 3 Neighboring gene STARR-positive B cell enhancer ABC_E7851 Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 Neighboring gene predicted gene 14137 Neighboring gene 40S ribosomal protein S6 (Phosphoprotein NP33)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP cyclohydrolase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP cyclohydrolase binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in negative regulation of biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
GTP cyclohydrolase 1 feedback regulatory protein
Names
GTP cyclohydrolase I feedback regulatory protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177157.4NP_796131.1  GTP cyclohydrolase 1 feedback regulatory protein

    See identical proteins and their annotated locations for NP_796131.1

    Status: PROVISIONAL

    Source sequence(s)
    AK028116
    Consensus CDS
    CCDS38204.1
    UniProtKB/Swiss-Prot
    P99025, Q8BH29
    UniProtKB/TrEMBL
    Q4VAF4
    Related
    ENSMUSP00000060835.4, ENSMUST00000057454.4
    Conserved Domains (1) summary
    pfam06399
    Location:383
    GFRP; GTP cyclohydrolase I feedback regulatory protein (GFRP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118998269..119002870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)