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Fry FRY microtubule binding protein [ Mus musculus (house mouse) ]

Gene ID: 320365, updated on 26-Sep-2022

Summary

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Official Symbol
Fryprovided by MGI
Official Full Name
FRY microtubule binding proteinprovided by MGI
Primary source
MGI:MGI:2443895
See related
Ensembl:ENSMUSG00000056602 AllianceGenome:MGI:2443895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cg003; 13CDNA73; mKIAA4143; D930046M03; 9330186A19Rik
Summary
Enables enzyme inhibitor activity. Involved in negative regulation of tubulin deacetylation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in cell cortex and site of polarized growth. Is expressed in several structures, including genitourinary system; nervous system; respiratory system cartilage; sensory organ; and skeleton. Orthologous to human FRY (FRY microtubule binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 11.0), subcutaneous fat pad adult (RPKM 10.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Fry in Genome Data Viewer
Location:
5 G3; 5 89.36 cM
Exon count:
67
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (150042083..150421218)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (150118618..150497753)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene soc-2 (suppressor of clear) homolog pseudogene Neighboring gene relaxin/insulin-like family peptide receptor 2 Neighboring gene predicted gene, 38755 Neighboring gene predicted gene, 52797 Neighboring gene predicted gene, 36299 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene zygote arrest 1-like Neighboring gene predicted gene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase. Nagai T, et al. J Cell Sci, 2013 Oct 1. PMID 23886946
  2. A transgenic insertion causing cryptorchidism in mice. Overbeek PA, et al. Genesis, 2001 May. PMID 11353515
  3. Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. Rios JJ, et al. J Bone Miner Res, 2021 Aug. PMID 33905568, Free PMC Article
  4. Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Coulpier F, et al. Glia, 2009 Oct. PMID 19243017
  5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4143

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of tubulin deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
protein furry homolog
Names
furry homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172887.2 → NP_766475.2  protein furry homolog

    See identical proteins and their annotated locations for NP_766475.2

    Status: VALIDATED

    Source sequence(s)
    AC084217, AK054402, AK086708, BC096532, BF471208, BU057159, CA327618, CA328551, CB520664, CF532608, CJ103680
    Consensus CDS
    CCDS51708.1
    UniProtKB/Swiss-Prot
    E9Q8I9, Q8CG91
    UniProtKB/TrEMBL
    Q8BIX6
    Related
    ENSMUSP00000084454.6, ENSMUST00000087204.9
    Conserved Domains (3) summary
    pfam14222
    Location:165 → 672
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2050 → 2303
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1141 → 1513
    MOR2-PAG1_mid; Cell morphogenesis central region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    150042083..150421218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504932.3 → XP_006504995.1  protein furry homolog isoform X8

    See identical proteins and their annotated locations for XP_006504995.1

    Conserved Domains (3) summary
    pfam14222
    Location:115 → 621
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2000 → 2253
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1091 → 1456
    MOR2-PAG1_mid; Cell morphogenesis central region

  2. XM_006504933.3 → XP_006504996.1  protein furry homolog isoform X8

    See identical proteins and their annotated locations for XP_006504996.1

    Conserved Domains (3) summary
    pfam14222
    Location:115 → 621
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2000 → 2253
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1091 → 1456
    MOR2-PAG1_mid; Cell morphogenesis central region

  3. XM_030254574.2 → XP_030110434.1  protein furry homolog isoform X8

    Conserved Domains (3) summary
    pfam14222
    Location:115 → 621
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2000 → 2253
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1091 → 1456
    MOR2-PAG1_mid; Cell morphogenesis central region

  4. XM_011241024.2 → XP_011239326.1  protein furry homolog isoform X2

    Conserved Domains (3) summary
    pfam14222
    Location:210 → 716
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2095 → 2348
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1186 → 1551
    MOR2-PAG1_mid; Cell morphogenesis central region

  5. XM_006504926.2 → XP_006504989.1  protein furry homolog isoform X1

    Conserved Domains (3) summary
    pfam14222
    Location:210 → 716
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2095 → 2348
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1186 → 1551
    MOR2-PAG1_mid; Cell morphogenesis central region

  6. XM_006504928.2 → XP_006504991.1  protein furry homolog isoform X4

    Conserved Domains (3) summary
    pfam14222
    Location:210 → 716
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2095 → 2348
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1186 → 1551
    MOR2-PAG1_mid; Cell morphogenesis central region

  7. XM_006504927.2 → XP_006504990.1  protein furry homolog isoform X3

    Conserved Domains (3) summary
    pfam14222
    Location:210 → 716
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2095 → 2348
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1186 → 1551
    MOR2-PAG1_mid; Cell morphogenesis central region

  8. XM_006504929.2 → XP_006504992.1  protein furry homolog isoform X5

    Conserved Domains (3) summary
    pfam14222
    Location:210 → 716
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2095 → 2348
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1186 → 1551
    MOR2-PAG1_mid; Cell morphogenesis central region

  9. XM_006504930.5 → XP_006504993.1  protein furry homolog isoform X6

    UniProtKB/Swiss-Prot
    E9Q8I9
    Conserved Domains (3) summary
    pfam14222
    Location:165 → 671
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2050 → 2303
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1141 → 1506
    MOR2-PAG1_mid; Cell morphogenesis central region

  10. XM_006504931.3 → XP_006504994.1  protein furry homolog isoform X7

    Related
    ENSMUSP00000158877.2, ENSMUST00000239118.2
    Conserved Domains (3) summary
    pfam14222
    Location:162 → 668
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2047 → 2300
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:1138 → 1503
    MOR2-PAG1_mid; Cell morphogenesis central region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178781.2: Suppressed sequence

    Description
    NM_178781.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q8I9.1 GenPept UniProtKB/Swiss-Prot:E9Q8I9

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