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Marchf3 membrane associated ring-CH-type finger 3 [ Mus musculus (house mouse) ]

Gene ID: 320253, updated on 12-May-2024

Summary

Official Symbol
Marchf3provided by MGI
Official Full Name
membrane associated ring-CH-type finger 3provided by MGI
Primary source
MGI:MGI:2443667
See related
Ensembl:ENSMUSG00000032656 AllianceGenome:MGI:2443667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
March3; MARCH-III; 6330411I15Rik; A530081L18Rik
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within endocytosis. Predicted to be located in endosome and lysosome. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and integumental system. Orthologous to human MARCHF3 (membrane associated ring-CH-type finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 13.9), liver E14 (RPKM 12.2) and 21 other tissues See more
Orthologs
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Genomic context

See Marchf3 in Genome Data Viewer
Location:
18 D3; 18 30.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56894788..57058587, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56761716..56925515, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10992 Neighboring gene predicted gene, 41738 Neighboring gene lamin B1 Neighboring gene STARR-seq mESC enhancer starr_44677 Neighboring gene predicted gene 15345 Neighboring gene VISTA enhancer mm109 Neighboring gene STARR-positive B cell enhancer ABC_E5663 Neighboring gene STARR-positive B cell enhancer ABC_E1959 Neighboring gene ribosomal protein S3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44682 Neighboring gene predicted gene, 34632 Neighboring gene RIKEN cDNA C330018D20 gene Neighboring gene predicted gene 10536

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

General gene information

Markers

Clone Names

  • MGC130167, MGC130168

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCHF3
Names
E3 ubiquitin-protein ligase MARCH3
RING-type E3 ubiquitin transferase MARCH3
RING-type E3 ubiquitin transferase MARCHF3
membrane-associated RING finger protein 3
membrane-associated RING-CH protein III
membrane-associated ring finger (C3HC4) 3
NP_001361156.1
NP_001361157.1
NP_796089.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374227.1NP_001361156.1  E3 ubiquitin-protein ligase MARCHF3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109152, AC158763
    Consensus CDS
    CCDS89244.1
    UniProtKB/TrEMBL
    F8WJC4
    Related
    ENSMUSP00000047946.7, ENSMUST00000035278.7
    Conserved Domains (1) summary
    cd16699
    Location:70120
    RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins
  2. NM_001374228.1NP_001361157.1  E3 ubiquitin-protein ligase MARCHF3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109152, AC158763
    Conserved Domains (1) summary
    cd16699
    Location:70120
    RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins
  3. NM_177115.3NP_796089.1  E3 ubiquitin-protein ligase MARCHF3 isoform 2

    See identical proteins and their annotated locations for NP_796089.1

    Status: VALIDATED

    Source sequence(s)
    AC109152, AC158763
    Consensus CDS
    CCDS29262.1
    UniProtKB/Swiss-Prot
    Q3KNK5, Q8BRX9
    Related
    ENSMUSP00000099976.2, ENSMUST00000102912.8
    Conserved Domains (1) summary
    cd16699
    Location:70120
    RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    56894788..57058587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)