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Senp5 SUMO/sentrin specific peptidase 5 [ Mus musculus (house mouse) ]

Gene ID: 320213, updated on 8-Nov-2022

Summary

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Official Symbol
Senp5provided by MGI
Official Full Name
SUMO/sentrin specific peptidase 5provided by MGI
Primary source
MGI:MGI:2443596
See related
Ensembl:ENSMUSG00000022772 AllianceGenome:MGI:2443596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SMT3IP3; 6230429P13Rik; A730063F07Rik
Summary
Predicted to enable SUMO-specific endopeptidase activity. Predicted to be involved in protein desumoylation. Predicted to act upstream of or within cell division. Predicted to be located in centrosome; cytosol; and nuclear lumen. Predicted to be active in nucleus. Is expressed in ganglia and heart. Orthologous to human SENP5 (SUMO specific peptidase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.7), CNS E11.5 (RPKM 4.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Senp5 in Genome Data Viewer
Location:
16; 16 B2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31778488..31829388, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31959670..32003287, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Ncbp2 antisense 2 (head to head) Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene Neighboring gene high mobility group box 1, pseudogene 6 Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene predicted gene, 26419 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development. Yamada S, et al. iScience, 2021 Dec 17. PMID 34988397, Free PMC Article
  2. Synaptic localization of the SUMOylation-regulating protease SENP5 in the adult mouse brain. Akiyama H, et al. J Comp Neurol, 2018 Apr 15. PMID 29277914
  3. SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy. Kim EY, et al. J Mol Cell Cardiol, 2015 Jan. PMID 25128087
  4. SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin. Nishida T, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18639523
  5. Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression. Zhang X, et al. PLoS One, 2020. PMID 33211757, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the present study demonstrate for the first time that SENP5 are ubiquitously distributed in the adult murine brain.
    Title: Synaptic localization of the SUMOylation-regulating protease SENP5 in the adult mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • DKFZp564O1016

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like protein peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
sentrin-specific protease 5
Names
SUMO/Smt3-specific isopeptidase 3
SUMO/sentrin specific protease 5
sentrin/SUMO-specific protease SENP5
NP_001344016.1
NP_001344017.1
NP_796077.2
XP_006522303.1
XP_006522305.1
XP_036015874.1
XP_036015875.1
XP_036015876.1
XP_036015877.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357087.1 → NP_001344016.1  sentrin-specific protease 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124681
    Consensus CDS
    CCDS28111.1
    UniProtKB/Swiss-Prot
    Q8BXW0
    Related
    ENSMUSP00000023457.6, ENSMUST00000023457.13
    Conserved Domains (2) summary
    pfam02902
    Location:575 → 747
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    pfam08766
    Location:488 → 545
    DEK_C; DEK C terminal domain

  2. NM_001357088.1 → NP_001344017.1  sentrin-specific protease 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124681
    Related
    ENSMUSP00000115257.2, ENSMUST00000129900.2
    Conserved Domains (2) summary
    COG5160
    Location:567 → 620
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    pfam08766
    Location:488 → 545
    DEK_C; DEK C terminal domain

  3. NM_177103.4 → NP_796077.2  sentrin-specific protease 5 isoform 1

    See identical proteins and their annotated locations for NP_796077.2

    Status: VALIDATED

    Source sequence(s)
    AC124681, AK028177, BC067014, BG146216
    Consensus CDS
    CCDS28111.1
    UniProtKB/Swiss-Prot
    Q6NXL6, Q8BXW0
    Related
    ENSMUSP00000156109.2, ENSMUST00000231360.2
    Conserved Domains (2) summary
    pfam02902
    Location:575 → 747
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    pfam08766
    Location:488 → 545
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    31778488..31829388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159982.1 → XP_036015875.1  sentrin-specific protease 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8BXW0
    Conserved Domains (2) summary
    pfam02902
    Location:575 → 747
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    pfam08766
    Location:488 → 545
    DEK_C; DEK C terminal domain

  2. XM_036159981.1 → XP_036015874.1  sentrin-specific protease 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8BXW0
    Conserved Domains (2) summary
    pfam02902
    Location:575 → 747
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    pfam08766
    Location:488 → 545
    DEK_C; DEK C terminal domain

  3. XM_006522242.5 → XP_006522305.1  sentrin-specific protease 5 isoform X3

    Conserved Domains (1) summary
    COG5160
    Location:567 → 702
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  4. XM_036159983.1 → XP_036015876.1  sentrin-specific protease 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8BXW0
    Conserved Domains (2) summary
    pfam02902
    Location:575 → 747
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    pfam08766
    Location:488 → 545
    DEK_C; DEK C terminal domain

  5. XM_036159984.1 → XP_036015877.1  sentrin-specific protease 5 isoform X4

    Conserved Domains (1) summary
    COG5160
    Location:6 → 187
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  6. XM_006522240.5 → XP_006522303.1  sentrin-specific protease 5 isoform X2

    Conserved Domains (1) summary
    cl23802
    Location:591 → 721
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RNA

  1. XR_004939195.1 RNA Sequence

  2. XR_003951796.2 RNA Sequence

  3. XR_004939194.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_023801.1: Suppressed sequence

    Description
    NM_023801.1: This RefSeq was permanently suppressed because it is entirely UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXL6.1 GenPept UniProtKB/Swiss-Prot:Q6NXL6

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