Format

Send to:

Choose Destination

HOXA5 homeobox A5 [ Homo sapiens (human) ]

Gene ID: 3202, updated on 7-Dec-2018

Summary

Official Symbol
HOXA5provided by HGNC
Official Full Name
homeobox A5provided by HGNC
Primary source
HGNC:HGNC:5106
See related
Ensembl:ENSG00000106004 MIM:142952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX1; HOX1C; HOX1.3
Summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 48.1), lung (RPKM 14.3) and 8 other tissues See more
Orthologs

Genomic context

See HOXA5 in Genome Data Viewer
Location:
7p15.2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (27141052..27143668, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27180671..27192309, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene homeobox A2 Neighboring gene homeobox A3 Neighboring gene HOXA cluster antisense RNA 2 Neighboring gene homeobox A4 Neighboring gene HOXA cluster antisense RNA 3 Neighboring gene homeobox A6 Neighboring gene homeobox A7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9376

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bronchiole development IEA
Inferred from Electronic Annotation
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling involved in mammary gland development IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epithelial tube branching involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
intestinal epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
lung goblet cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lung-associated mesenchyme development IEA
Inferred from Electronic Annotation
more info
 
mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
mammary gland epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mesenchymal-epithelial cell signaling IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of receptor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
respiratory system process IEA
Inferred from Electronic Annotation
more info
 
thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
trachea cartilage morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein Hox-A5
Names
homeo box 1C
homeo box A5
homeobox protein HOXA5
homeobox protein Hox-1C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019102.4NP_061975.2  homeobox protein Hox-A5

    See identical proteins and their annotated locations for NP_061975.2

    Status: REVIEWED

    Source sequence(s)
    AC004080, BC013682, BI822268
    Consensus CDS
    CCDS5406.1
    UniProtKB/Swiss-Prot
    P20719
    Related
    ENSP00000222726.3, ENST00000222726.3
    Conserved Domains (1) summary
    pfam00046
    Location:199251
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    27141052..27143668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center