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Msrb3 methionine sulfoxide reductase B3 [ Mus musculus (house mouse) ]

Gene ID: 320183, updated on 18-Apr-2024

Summary

Official Symbol
Msrb3provided by MGI
Official Full Name
methionine sulfoxide reductase B3provided by MGI
Primary source
MGI:MGI:2443538
See related
Ensembl:ENSMUSG00000051236 AllianceGenome:MGI:2443538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MsrB2; I-8-23; D430026P16Rik
Summary
Predicted to enable peptide-methionine (R)-S-oxide reductase activity and zinc ion binding activity. Predicted to be involved in protein repair. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including heart; inner ear; jaw; limb; and skeleton. Used to study autosomal recessive nonsyndromic deafness 74. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to human MSRB3 (methionine sulfoxide reductase B3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 52.3), heart adult (RPKM 20.8) and 14 other tissues See more
Orthologs
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Genomic context

Location:
10 D2; 10 68.75 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (120617005..120735132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (120781100..120899011, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921513I03 gene Neighboring gene predicted gene, 35182 Neighboring gene STARR-seq mESC enhancer starr_28072 Neighboring gene STARR-seq mESC enhancer starr_28073 Neighboring gene predicted gene 15910 Neighboring gene STARR-positive B cell enhancer ABC_E581 Neighboring gene predicted gene 4473 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene LEM domain containing 3 Neighboring gene predicted gene, 50589

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-methionine-(R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables peptide-methionine (R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide-methionine (R)-S-oxide reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide-methionine (R)-S-oxide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in protein repair ISO
Inferred from Sequence Orthology
more info
 
involved_in protein repair ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
methionine-R-sulfoxide reductase B3, mitochondrial
NP_001393328.1
NP_001393329.1
NP_796066.1
XP_036011713.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001406399.1NP_001393328.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138388
  2. NM_001406400.1NP_001393329.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138388
    UniProtKB/TrEMBL
    D3YUC9
    Related
    ENSMUSP00000115269.2, ENSMUST00000130950.2
  3. NM_177092.5NP_796066.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_796066.1

    Status: VALIDATED

    Source sequence(s)
    AC138388
    Consensus CDS
    CCDS24208.1
    UniProtKB/TrEMBL
    A0A0R4J139
    Related
    ENSMUSP00000089781.6, ENSMUST00000092143.12
    Conserved Domains (1) summary
    PRK00222
    Location:35171
    PRK00222; peptide-methionine (R)-S-oxide reductase MsrB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    120617005..120735132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155820.1XP_036011713.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform X2