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Zdhhc17 zinc finger, DHHC domain containing 17 [ Mus musculus (house mouse) ]

Gene ID: 320150, updated on 12-May-2024

Summary

Official Symbol
Zdhhc17provided by MGI
Official Full Name
zinc finger, DHHC domain containing 17provided by MGI
Primary source
MGI:MGI:2445110
See related
Ensembl:ENSMUSG00000035798 AllianceGenome:MGI:2445110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hip14; DHHC-17; A230053P19Rik; D130071N24Rik
Summary
Enables palmitoyltransferase activity and signaling receptor binding activity. Involved in axonogenesis; peptidyl-L-cysteine S-palmitoylation; and regulation of signal transduction. Acts upstream of or within protein palmitoylation. Located in Golgi apparatus. Is expressed in several structures, including early conceptus; heart; and oocyte. Used to study Huntington's disease. Orthologous to human ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 24.0), CNS E18 (RPKM 21.9) and 25 other tissues See more
Orthologs
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Genomic context

See Zdhhc17 in Genome Data Viewer
Location:
10 D1; 10 57.86 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (110777640..110848587, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (110941779..111010066, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22236 Neighboring gene cysteine and glycine-rich protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E9351 Neighboring gene predicted gene, 51781 Neighboring gene predicted gene, 29916

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0946

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-myristoyltransferase activity IC
Inferred by Curator
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IC
Inferred by Curator
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-cysteine S-stearoyltransferase activity IC
Inferred by Curator
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi-associated vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in perforant pathway to dendrate granule cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in perforant pathway to dendrate granule cell synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC17
Names
DHHC domain-containing cysteine-rich protein 17
acyltransferase ZDHHC17
acyltransferase ZDHHC7
huntingtin interacting protein 14
zinc finger DHHC domain-containing protein 17
NP_001346551.1
NP_001346553.1
NP_766142.2
XP_030100985.1
XP_036011712.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359622.1NP_001346551.1  palmitoyltransferase ZDHHC17 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a shorter 5' UTR than variant 1, and initiates translation at a downstream start codon, compared to variant 1. This variant intiates transcription from a major transcription start site, as determined by CAGE data. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK038670, AK046891, AW911453, BE955669, BQ560505
    UniProtKB/TrEMBL
    Q0VFY6
    Conserved Domains (3) summary
    cd00204
    Location:77192
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:146177
    ANK; ANK repeat [structural motif]
    pfam01529
    Location:428558
    zf-DHHC; DHHC palmitoyltransferase
  2. NM_001359624.1NP_001346553.1  palmitoyltransferase ZDHHC17 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site, resulting in translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning results in translation initiation at the downstream start codon to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK039575, AW911453, BC027101, BE955669
    Conserved Domains (1) summary
    pfam01529
    Location:166296
    DHHC; DHHC palmitoyltransferase
  3. NM_172554.2NP_766142.2  palmitoyltransferase ZDHHC17 isoform 1

    See identical proteins and their annotated locations for NP_766142.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK039575, AK046891, AW911453, BC027101, BC051527
    Consensus CDS
    CCDS56748.1
    UniProtKB/Swiss-Prot
    Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6
    Related
    ENSMUSP00000043279.8, ENSMUST00000041723.15
    Conserved Domains (4) summary
    PHA03095
    Location:100352
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:156187
    ANK; ANK repeat [structural motif]
    pfam01529
    Location:438568
    DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:161255
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    110777640..110848587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155819.1XP_036011712.1  palmitoyltransferase ZDHHC17 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:186316
    DHHC; DHHC palmitoyltransferase
  2. XM_030245125.2XP_030100985.1  palmitoyltransferase ZDHHC17 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:186316
    DHHC; DHHC palmitoyltransferase