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S spike glycoprotein [ Human coronavirus HKU1 ]

Gene ID: 3200426, updated on 18-Aug-2023
Gene symbol
S
Gene description
spike glycoprotein
Locus tag
HCHV1gp3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human coronavirus HKU1 (isolate: HKU1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Embecovirus
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Sequence:
NC_006577.2 (22942..27012)

NC_006577.2Genomic Context describing neighboring genes Neighboring gene ORF1a polyprotein;ORF1ab polyprotein Neighboring gene hemagglutinin-esterase glycoprotein Neighboring gene non-structural protein Neighboring gene envelope protein Neighboring gene membrane glycoprotein

Genomic Sequence:
NC_006577.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1. Ou X, et al. Nat Commun, 2017 May 23. PMID 28534504, Free PMC Article
  2. Pre-fusion structure of a human coronavirus spike protein. Kirchdoerfer RN, et al. Nature, 2016 Mar 3. PMID 26935699, Free PMC Article
  3. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. Woo PC, et al. J Virol, 2005 Jan. PMID 15613317, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the crystal structure of HKU1 spike glycoprotein C-terminal domain at 1.9 A resolution, is reported.[Spike].
    Title: Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1.
  2. 4.0 A resolution structure of the trimeric HKU1 S protein determined using single-particle cryo-electron microscopy
    Title: Pre-fusion structure of a human coronavirus spike protein.
Submit: New GeneRIF Correction
Preferred Names
spike glycoprotein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006577.2 Reference assembly

    Range
    22942..27012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_173238.1 spike glycoprotein [Human coronavirus HKU1]

    See identical proteins and their annotated locations for YP_173238.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q5MQD0
    UniProtKB/TrEMBL
    Q19U42
    Conserved Domains (4) summary
    pfam01600
    Location:619 → 713
    Corona_S1; Coronavirus S1 glycoprotein
    pfam01601
    Location:769 → 1339
    Corona_S2; Coronavirus S2 glycoprotein
    pfam09408
    Location:322 → 526
    Spike_rec_bind; Spike receptor binding domain
    pfam16451
    Location:15 → 288
    Spike_NTD; Spike glycoprotein N-terminal domain
Nucleotide Protein
Heading Accession and Version

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