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ACACB acetyl-CoA carboxylase beta [ Homo sapiens (human) ]

Gene ID: 32, updated on 5-Aug-2018

Summary

Official Symbol
ACACBprovided by HGNC
Official Full Name
acetyl-CoA carboxylase betaprovided by HGNC
Primary source
HGNC:HGNC:85
See related
Ensembl:ENSG00000076555 MIM:601557; Vega:OTTHUMG00000169250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACC2; ACCB; HACC275
Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 94.8), liver (RPKM 8.9) and 6 other tissues See more
Orthologs

Genomic context

See ACACB in Genome Data Viewer
Location:
12q24.11
Exon count:
56
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (109112666..109268226)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109554222..109706031)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Neighboring gene uncharacterized LOC105369974 Neighboring gene uracil DNA glycosylase Neighboring gene forkhead box N4 Neighboring gene long intergenic non-protein coding RNA 1486

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of acetyl-CoA carboxylase beta (ACACB) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with ACACB as demonstrated by proximity dependent biotinylation proteomics PubMed
Tat tat Knockdown of acetyl-Coenzyme A carboxylase beta (ACACB) by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed
tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
acetyl-CoA carboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
acetyl-CoA carboxylase activity TAS
Traceable Author Statement
more info
 
biotin binding IEA
Inferred from Electronic Annotation
more info
 
biotin carboxylase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acetyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
carnitine shuttle TAS
Traceable Author Statement
more info
 
energy homeostasis IEA
Inferred from Electronic Annotation
more info
 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
malonyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular metabolic process TAS
Traceable Author Statement
more info
 
positive regulation of heart growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid storage IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cholesterol biosynthetic process TAS
Traceable Author Statement
more info
 
regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
acetyl-CoA carboxylase 2
Names
ACC-beta
acetyl-Coenzyme A carboxylase beta
NP_001084.3
XP_005253933.1
XP_006719430.1
XP_011536561.1
XP_011536565.1
XP_011536566.1
XP_011536567.1
XP_016874741.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046907.1 RefSeqGene

    Range
    33214..162043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001093.3NP_001084.3  acetyl-CoA carboxylase 2 precursor

    See identical proteins and their annotated locations for NP_001084.3

    Status: REVIEWED

    Source sequence(s)
    AJ575592, AY382667, BC009753, CB269093, CB269579, DB567934, R99037
    Consensus CDS
    CCDS31898.1
    UniProtKB/Swiss-Prot
    O00763
    Related
    ENSP00000367079.3, ENST00000377848.7
    Conserved Domains (7) summary
    COG0439
    Location:260763
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:260379
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:895961
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17802328
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:650757
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:9621688
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:420613
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    109112666..109268226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538265.2XP_011536567.1  acetyl-CoA carboxylase 2 isoform X6

    Conserved Domains (6) summary
    COG0439
    Location:260763
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:260379
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:895961
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam02785
    Location:650757
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:9621294
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:420613
    ATP-grasp_4; ATP-grasp domain
  2. XM_011538259.2XP_011536561.1  acetyl-CoA carboxylase 2 isoform X1

    See identical proteins and their annotated locations for XP_011536561.1

    UniProtKB/Swiss-Prot
    O00763
    Conserved Domains (7) summary
    COG0439
    Location:260763
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:260379
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:895961
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17802328
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:650757
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:9621688
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:420613
    ATP-grasp_4; ATP-grasp domain
  3. XM_011538263.3XP_011536565.1  acetyl-CoA carboxylase 2 isoform X2

    Conserved Domains (7) summary
    COG0439
    Location:260763
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:260379
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:895961
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17172265
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:650757
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:9621625
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:420613
    ATP-grasp_4; ATP-grasp domain
  4. XM_011538264.3XP_011536566.1  acetyl-CoA carboxylase 2 isoform X4

    Conserved Domains (7) summary
    COG0439
    Location:51554
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:51170
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:686752
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:15712119
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:441548
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:7531479
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:211404
    ATP-grasp_4; ATP-grasp domain
  5. XM_005253876.4XP_005253933.1  acetyl-CoA carboxylase 2 isoform X1

    See identical proteins and their annotated locations for XP_005253933.1

    UniProtKB/Swiss-Prot
    O00763
    Related
    ENSP00000341044.7, OTTHUMP00000240532, ENST00000338432.11, OTTHUMT00000403077
    Conserved Domains (7) summary
    COG0439
    Location:260763
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:260379
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:895961
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17802328
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:650757
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:9621688
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:420613
    ATP-grasp_4; ATP-grasp domain
  6. XM_006719367.4XP_006719430.1  acetyl-CoA carboxylase 2 isoform X3

    UniProtKB/Swiss-Prot
    O00763
    Conserved Domains (7) summary
    COG0439
    Location:58561
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:58177
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:693759
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:15782126
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:448555
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:7601486
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:218411
    ATP-grasp_4; ATP-grasp domain
  7. XM_017019252.2XP_016874741.1  acetyl-CoA carboxylase 2 isoform X5

RNA

  1. XR_944532.3 RNA Sequence

  2. XR_002957320.1 RNA Sequence

  3. XR_002957321.1 RNA Sequence

  4. XR_944530.2 RNA Sequence

    Related
    ENST00000377854.9
  5. XR_002957322.1 RNA Sequence

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