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HOXA2 homeobox A2 [ Homo sapiens (human) ]

Gene ID: 3199, updated on 13-Feb-2019

Summary

Official Symbol
HOXA2provided by HGNC
Official Full Name
homeobox A2provided by HGNC
Primary source
HGNC:HGNC:5103
See related
Ensembl:ENSG00000105996 MIM:604685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX1K; MCOHI
Summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 1.2), fat (RPKM 0.8) and 19 other tissues See more
Orthologs

Genomic context

See HOXA2 in Genome Data Viewer
Location:
7p15.2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (27100354..27102775, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27139973..27142394, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene homeobox A1 Neighboring gene HOXA transcript antisense RNA, myeloid-specific 1 Neighboring gene homeobox A3 Neighboring gene HOXA cluster antisense RNA 2 Neighboring gene homeobox A4 Neighboring gene HOXA cluster antisense RNA 3 Neighboring gene homeobox A5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain segmentation IEA
Inferred from Electronic Annotation
more info
 
cell fate determination IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
dorsal/ventral pattern formation IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryonic viscerocranium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
middle ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
osteoblast development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rhombomere 2 development IEA
Inferred from Electronic Annotation
more info
 
rhombomere 3 morphogenesis IEA
Inferred from Electronic Annotation
more info
 
segment specification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
homeobox protein Hox-A2
Names
homeobox protein Hox-1K

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012078.2 RefSeqGene

    Range
    5001..7422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006735.4NP_006726.1  homeobox protein Hox-A2

    See identical proteins and their annotated locations for NP_006726.1

    Status: REVIEWED

    Source sequence(s)
    AI581335, AI796505, AW292406, BE465040, BF509655
    Consensus CDS
    CCDS5403.1
    UniProtKB/Swiss-Prot
    O43364
    Related
    ENSP00000222718.5, ENST00000222718.6
    Conserved Domains (1) summary
    pfam00046
    Location:147199
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    27100354..27102775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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