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Ttll1 tubulin tyrosine ligase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 319953, updated on 5-Jan-2023

Summary

Official Symbol
Ttll1provided by MGI
Official Full Name
tubulin tyrosine ligase-like 1provided by MGI
Primary source
MGI:MGI:2443047
See related
Ensembl:ENSMUSG00000022442 AllianceGenome:MGI:2443047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330444E16Rik
Summary
Enables tubulin-glutamic acid ligase activity. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; mucociliary clearance; and protein polyglutamylation. Located in ciliary basal body. Used to study primary ciliary dyskinesia. Orthologous to human TTLL1 (tubulin tyrosine ligase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 14.5), CNS E18 (RPKM 14.3) and 26 other tissues See more
Orthologs
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Genomic context

See Ttll1 in Genome Data Viewer
Location:
15; 15 E1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83367258..83402675, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83483057..83518474, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene protein kinase C and casein kinase substrate in neurons 2 Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 pseudogene 1 Neighboring gene predicted gene, 52181 Neighboring gene predicted gene, 46495 Neighboring gene BCL2-interacting killer Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin-glutamic acid ligase activity EXP
Inferred from Experiment
more info
PubMed 
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin-glutamic acid ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune response in nasopharyngeal-associated lymphoid tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mucociliary clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein polyglutamylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein polyglutamylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein polyglutamylation TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within regulation of blastocyst development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
polyglutamylase complex subunit TTLL1; probable tubulin polyglutamylase TTLL1
Names
PGs3
p49
tubulin polyglutamylase TTLL1
tubulin polyglutamylase complex subunit 3
tubulin--tyrosine ligase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357953.1NP_001344882.1  polyglutamylase complex subunit TTLL1

    Status: VALIDATED

    Source sequence(s)
    AL583889
    Consensus CDS
    CCDS27702.1
    UniProtKB/Swiss-Prot
    Q91ZG1
    UniProtKB/TrEMBL
    A0A6P5R8H9
    Conserved Domains (1) summary
    pfam03133
    Location:59364
    TTL; Tubulin-tyrosine ligase family
  2. NM_178869.4NP_849200.2  polyglutamylase complex subunit TTLL1

    See identical proteins and their annotated locations for NP_849200.2

    Status: VALIDATED

    Source sequence(s)
    AK140472, AK168786, AK169150, BY091756
    Consensus CDS
    CCDS27702.1
    UniProtKB/Swiss-Prot
    Q91V51, Q91ZG1
    UniProtKB/TrEMBL
    A0A6P5R8H9
    Related
    ENSMUSP00000016897.5, ENSMUST00000016897.12
    Conserved Domains (1) summary
    pfam03133
    Location:59364
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83367258..83402675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248606.2XP_030104466.1  probable tubulin polyglutamylase TTLL1 isoform X2

    Conserved Domains (1) summary
    pfam03133
    Location:2264
    TTL; Tubulin-tyrosine ligase family
  2. XM_006521078.4XP_006521141.1  probable tubulin polyglutamylase TTLL1 isoform X1

    See identical proteins and their annotated locations for XP_006521141.1

    UniProtKB/Swiss-Prot
    Q91V51, Q91ZG1
    UniProtKB/TrEMBL
    A0A6P5R8H9
    Conserved Domains (1) summary
    pfam03133
    Location:59364
    TTL; Tubulin-tyrosine ligase family