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Tns3 tensin 3 [ Mus musculus (house mouse) ]

Gene ID: 319939, updated on 11-Apr-2024

Summary

Official Symbol
Tns3provided by MGI
Official Full Name
tensin 3provided by MGI
Primary source
MGI:MGI:2443012
See related
Ensembl:ENSMUSG00000020422 AllianceGenome:MGI:2443012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TEM6; Tens1; F830010I22Rik
Summary
Acts upstream of or within cell migration; lung alveolus development; and positive regulation of cell population proliferation. Predicted to be located in cytosol and focal adhesion. Is expressed in several structures, including craniocervical region bone; foot mesenchyme; reproductive system; spleen primordium; and tail. Orthologous to human TNS3 (tensin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 31.3), ovary adult (RPKM 22.7) and 27 other tissues See more
Orthologs
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Genomic context

Location:
11 A1; 11 4.99 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (8381652..8614758, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (8431652..8664758, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA aspartic acid 10 (anticodon GTC) Neighboring gene predicted gene, 27393 Neighboring gene STARR-seq mESC enhancer starr_28503 Neighboring gene STARR-seq mESC enhancer starr_28504 Neighboring gene STARR-seq mESC enhancer starr_28506 Neighboring gene STARR-seq mESC enhancer starr_28507 Neighboring gene STARR-seq mESC enhancer starr_28508 Neighboring gene STARR-seq mESC enhancer starr_28509 Neighboring gene STARR-seq mESC enhancer starr_28511 Neighboring gene STARR-seq mESC enhancer starr_28512 Neighboring gene STARR-seq mESC enhancer starr_28518 Neighboring gene STARR-seq mESC enhancer starr_28520 Neighboring gene STARR-seq mESC enhancer starr_28524 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:8501700-8501809 Neighboring gene STARR-seq mESC enhancer starr_28532 Neighboring gene STARR-seq mESC enhancer starr_28533 Neighboring gene STARR-seq mESC enhancer starr_28537 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:8600745-8600973 Neighboring gene STARR-seq mESC enhancer starr_28543 Neighboring gene STARR-seq mESC enhancer starr_28544 Neighboring gene STARR-seq mESC enhancer starr_28546 Neighboring gene predicted gene, 36772 Neighboring gene general transcription factor II A, 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tensin-3
Names
tensin-like SH2 domain containing 1
tensin-like SH2 domain-containing protein 1
tumor endothelial marker 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083587.1NP_001077056.1  tensin-3

    See identical proteins and their annotated locations for NP_001077056.1

    Status: VALIDATED

    Source sequence(s)
    AK052680, AK158101, AL603845, AL662881, AW259174, BU056564, BY154424
    Consensus CDS
    CCDS36109.1
    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Related
    ENSMUSP00000020695.7, ENSMUST00000020695.13
    Conserved Domains (6) summary
    cd09927
    Location:11631279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7941073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:13031434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    8381652..8614758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156761.1XP_036012654.1  tensin-3 isoform X2

    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (7) summary
    cd09927
    Location:13121428
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:9431222
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:6811113
    PHA03307; transcriptional regulator ICP4; Provisional
    cd14561
    Location:157315
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:322448
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd20889
    Location:69124
    C1_TNS3_v; protein kinase C conserved region 1 (C1 domain) found in tensin-3 (TNS3) variant and similar proteins
    cl17171
    Location:14521511
    PH-like; Pleckstrin homology-like domain
  2. XM_036156762.1XP_036012655.1  tensin-3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:11631279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7941073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:13031434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
  3. XM_006514741.3XP_006514804.1  tensin-3 isoform X3

    See identical proteins and their annotated locations for XP_006514804.1

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:11631279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7941073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:13031434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
  4. XM_036156764.1XP_036012657.1  tensin-3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:11631279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7941073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:13031434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
  5. XM_011243728.4XP_011242030.1  tensin-3 isoform X3

    See identical proteins and their annotated locations for XP_011242030.1

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:11631279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7941073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:13031434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
  6. XM_011243727.3XP_011242029.1  tensin-3 isoform X1

    UniProtKB/TrEMBL
    A0A5F8MP98, A0A5F8MPF2
    Related
    ENSMUSP00000158873.2, ENSMUST00000239091.2
    Conserved Domains (7) summary
    cd09927
    Location:12761392
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:9071186
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:6451077
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00029
    Location:3581
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:14161547
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:121279
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:286412
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
  7. XM_030246087.1XP_030101947.1  tensin-3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:11631279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7941073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:13031434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
  8. XM_036156763.1XP_036012656.1  tensin-3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:11631279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7941073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:13031434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
  9. XM_006514740.4XP_006514803.2  tensin-3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:11631279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7941073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:13031434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
  10. XM_006514743.5XP_006514806.1  tensin-3 isoform X4

    Conserved Domains (3) summary
    cd09927
    Location:790906
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:421700
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:9301061
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

RNA

  1. XR_380972.4 RNA Sequence