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Apba1 amyloid beta (A4) precursor protein binding, family A, member 1 [ Mus musculus (house mouse) ]

Gene ID: 319924, updated on 15-Apr-2019

Summary

Official Symbol
Apba1provided by MGI
Official Full Name
amyloid beta (A4) precursor protein binding, family A, member 1provided by MGI
Primary source
MGI:MGI:1860297
See related
Ensembl:ENSMUSG00000024897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
X11; Mint; Mint1; Lin-10; Urop11; X11alpha; 6430513E09Rik
Expression
Broad expression in cortex adult (RPKM 21.6), cerebellum adult (RPKM 21.4) and 17 other tissues See more
Orthologs

Genomic context

See Apba1 in Genome Data Viewer
Location:
19; 19 B
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (23758806..23949598)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (23833366..24024087)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene SAP domain containing ribonucleoprotein pseudogene Neighboring gene protein prenyltransferase alpha subunit repeat containing 1 Neighboring gene predicted gene, 34076 Neighboring gene family with sequence similarity 189, member A2 Neighboring gene predicted gene, 41823

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
gamma-aminobutyric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamate secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular protein transport IPI
Inferred from Physical Interaction
more info
PubMed 
locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
amyloid-beta A4 precursor protein-binding family A member 1; amyloid beta A4 precursor protein-binding family A member 1
Names
UROP11-110
adapter protein X11alpha
mint-1
neuron-specific X11 protein
neuronal Munc18-1-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177034.3NP_796008.2  amyloid-beta A4 precursor protein-binding family A member 1

    See identical proteins and their annotated locations for NP_796008.2

    Status: VALIDATED

    Source sequence(s)
    AI838602, AK032261, AK147583, CJ122547
    Consensus CDS
    CCDS50407.1
    UniProtKB/Swiss-Prot
    B2RUJ5
    Related
    ENSMUSP00000025830.7, ENSMUST00000025830.8
    Conserved Domains (3) summary
    cd00992
    Location:750823
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:457628
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:661744
    PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    23758806..23949598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527139.3XP_006527202.1  amyloid beta A4 precursor protein-binding family A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006527202.1

    UniProtKB/Swiss-Prot
    B2RUJ5
    Conserved Domains (3) summary
    cd00992
    Location:750823
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:457628
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:661744
    PDZ; PDZ domain (Also known as DHR or GLGF)
  2. XM_006527140.3XP_006527203.1  amyloid beta A4 precursor protein-binding family A member 1 isoform X2

    UniProtKB/Swiss-Prot
    B2RUJ5
    Conserved Domains (3) summary
    cd00992
    Location:739812
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:457617
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:650733
    PDZ; PDZ domain (Also known as DHR or GLGF)
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