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Dsel dermatan sulfate epimerase-like [ Mus musculus (house mouse) ]

Gene ID: 319901, updated on 15-Jan-2023

Summary

Official Symbol
Dselprovided by MGI
Official Full Name
dermatan sulfate epimerase-likeprovided by MGI
Primary source
MGI:MGI:2442948
See related
Ensembl:ENSMUSG00000038702 AllianceGenome:MGI:2442948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DS-epi2; 9330132E09Rik
Summary
Enables chondroitin-glucuronate 5-epimerase activity. Acts upstream of or within chondroitin sulfate metabolic process and dermatan sulfate metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in eye. Orthologous to human DSEL (dermatan sulfate epimerase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 4.2), bladder adult (RPKM 2.7) and 25 other tissues See more
Orthologs
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Genomic context

See Dsel in Genome Data Viewer
Location:
1; 1 E2.1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (111786431..111792782, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (111858701..111865052, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921525D07 gene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene ribosomal protein L9 pseudogene Neighboring gene CCR4-NOT transcription complex, subunit 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chondroitin-glucuronate 5-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chondroitin-glucuronate 5-epimerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dermatan-sulfate epimerase-like protein
NP_001074785.1
XP_017176672.1
XP_030110808.1
XP_036021587.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081316.2NP_001074785.1  dermatan-sulfate epimerase-like protein precursor

    See identical proteins and their annotated locations for NP_001074785.1

    Status: VALIDATED

    Source sequence(s)
    AC125403
    Consensus CDS
    CCDS35688.1
    UniProtKB/Swiss-Prot
    B2RQ79, Q0VBN2
    Related
    ENSMUSP00000043570.6, ENSMUST00000035462.7
    Conserved Domains (1) summary
    cl21551
    Location:10891146
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    111786431..111792782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254948.1XP_030110808.1  dermatan-sulfate epimerase-like protein isoform X1

    UniProtKB/Swiss-Prot
    B2RQ79
    Conserved Domains (1) summary
    cl21551
    Location:10891146
    Sulfotransfer_3; Sulfotransferase family
  2. XM_036165694.1XP_036021587.1  dermatan-sulfate epimerase-like protein isoform X1

    UniProtKB/Swiss-Prot
    B2RQ79
    Conserved Domains (1) summary
    cl21551
    Location:10891146
    Sulfotransfer_3; Sulfotransferase family
  3. XM_017321183.3XP_017176672.1  dermatan-sulfate epimerase-like protein isoform X1

    UniProtKB/Swiss-Prot
    B2RQ79, Q0VBN2
    Conserved Domains (1) summary
    cl21551
    Location:10891146
    Sulfotransfer_3; Sulfotransferase family