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Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 319765, updated on 31-Jan-2023

Summary

Official Symbol
Igf2bp2provided by MGI
Official Full Name
insulin-like growth factor 2 mRNA binding protein 2provided by MGI
Primary source
MGI:MGI:1890358
See related
Ensembl:ENSMUSG00000033581 AllianceGenome:MGI:1890358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Imp2; IMP-2; Neilsen; C330012H03Rik
Summary
Predicted to enable mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Predicted to be involved in nervous system development; regulation of RNA metabolic process; and regulation of gene expression. Predicted to act upstream of or within mRNA transport and regulation of translation. Predicted to be located in cytoskeleton. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; early conceptus; gonad; liver; and otocyst. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 16.2), limb E14.5 (RPKM 16.1) and 17 other tissues See more
Orthologs
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Genomic context

See Igf2bp2 in Genome Data Viewer
Location:
16; 16 B1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (21877759..21982049, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22059009..22163299, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene SUMO/sentrin specific peptidase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit A11B Neighboring gene predicted gene, 25810 Neighboring gene transmembrane protein 97 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N6-methyladenosine-containing RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables translation regulator activity, nucleic acid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin-like growth factor 2 mRNA-binding protein 2
Names
IGF-II mRNA-binding protein 2
IGF2 mRNA-binding protein 2
VICKZ family member 2
insulin-like growth factor 2, binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183029.2NP_898850.2  insulin-like growth factor 2 mRNA-binding protein 2

    See identical proteins and their annotated locations for NP_898850.2

    Status: VALIDATED

    Source sequence(s)
    BC054552, BU708344, BY512142, CB290059
    Consensus CDS
    CCDS49797.1
    UniProtKB/Swiss-Prot
    Q5SF07, Q7TQF9
    Related
    ENSMUSP00000097629.5, ENSMUST00000100052.11
    Conserved Domains (6) summary
    cd12626
    Location:278
    RRM1_IGF2BP2; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd12629
    Location:82157
    RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd22491
    Location:188261
    KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22497
    Location:419495
    KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22500
    Location:502579
    KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cl00098
    Location:265360
    KH-I; K homology (KH) RNA-binding domain, type I

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    21877759..21982049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)