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Simc1 SUMO-interacting motifs containing 1 [ Mus musculus (house mouse) ]

Gene ID: 319719, updated on 26-Sep-2022

Summary

Official Symbol
Simc1provided by MGI
Official Full Name
SUMO-interacting motifs containing 1provided by MGI
Primary source
MGI:MGI:2442599
See related
Ensembl:ENSMUSG00000043183 AllianceGenome:MGI:2442599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732471D19Rik
Summary
Predicted to enable SUMO polymer binding activity and peptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in sarcomere. Orthologous to human SIMC1 (SUMO interacting motifs containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.4), CNS E18 (RPKM 7.6) and 28 other tissues See more
Orthologs
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Genomic context

See Simc1 in Genome Data Viewer
Location:
13; 13 B1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54651539..54699103)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54503739..54551290)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene THO complex 3 Neighboring gene predicted gene, 53205 Neighboring gene predicted gene 2830 Neighboring gene RIKEN cDNA 4833439L19 gene Neighboring gene predicted gene, 24195 Neighboring gene ADP-ribosylation factor-like 10 Neighboring gene NOP16 nucleolar protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO polymer binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SUMO polymer binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables peptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
SUMO-interacting motif-containing protein 1
Names
platform element for inhibition of autolytic degradation

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176987.5NP_795961.3  SUMO-interacting motif-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AC155262, AC165145
    Consensus CDS
    CCDS26528.2
    UniProtKB/Swiss-Prot
    Q8CE66
    UniProtKB/TrEMBL
    E9Q6E9, Q505H0
    Related
    ENSMUSP00000113676.2, ENSMUST00000121401.8
    Conserved Domains (2) summary
    PHA02682
    Location:194283
    PHA02682; ORF080 virion core protein; Provisional
    pfam09606
    Location:414807
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54651539..54699103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244528.2XP_011242830.1  SUMO-interacting motif-containing protein 1 isoform X1

    Conserved Domains (2) summary
    PHA02682
    Location:194283
    PHA02682; ORF080 virion core protein; Provisional
    pfam09606
    Location:327693
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  2. XM_011244529.2XP_011242831.1  SUMO-interacting motif-containing protein 1 isoform X2

    Conserved Domains (2) summary
    PHA02682
    Location:194283
    PHA02682; ORF080 virion core protein; Provisional
    pfam09606
    Location:369772
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  3. XM_036158068.1XP_036013961.1  SUMO-interacting motif-containing protein 1 isoform X4

    Conserved Domains (2) summary
    PHA02682
    Location:86175
    PHA02682; ORF080 virion core protein; Provisional
    PHA03307
    Location:413712
    PHA03307; transcriptional regulator ICP4; Provisional
  4. XM_017315526.2XP_017171015.1  SUMO-interacting motif-containing protein 1 isoform X5

  5. XM_011244530.1XP_011242832.1  SUMO-interacting motif-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011242832.1

    Conserved Domains (2) summary
    PHA02682
    Location:86175
    PHA02682; ORF080 virion core protein; Provisional
    pfam09606
    Location:219585
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  6. XM_030247294.1XP_030103154.1  SUMO-interacting motif-containing protein 1 isoform X5

  7. XM_011244531.1XP_011242833.1  SUMO-interacting motif-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011242833.1

    Conserved Domains (2) summary
    PHA02682
    Location:86175
    PHA02682; ORF080 virion core protein; Provisional
    pfam09606
    Location:219585
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal