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Fbxo48 F-box protein 48 [ Mus musculus (house mouse) ]

Gene ID: 319701, updated on 5-Mar-2024

Summary

Official Symbol
Fbxo48provided by MGI
Official Full Name
F-box protein 48provided by MGI
Primary source
MGI:MGI:2442569
See related
Ensembl:ENSMUSG00000044966 AllianceGenome:MGI:2442569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630050E13Rik
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in axial skeleton; liver; midbrain ventricular layer; and telencephalon ventricular layer. Orthologous to human FBXO48 (F-box protein 48). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 2.1), liver E14.5 (RPKM 1.8) and 20 other tissues See more
Orthologs
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Genomic context

See Fbxo48 in Genome Data Viewer
Location:
11 A2; 11 9.41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16901225..16908516)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16951224..16954777)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor receptor Neighboring gene predicted gene, 39584 Neighboring gene STARR-seq mESC enhancer starr_28696 Neighboring gene epidermal growth factor receptor, opposite strand Neighboring gene STARR-seq mESC enhancer starr_28697 Neighboring gene STARR-seq mESC enhancer starr_28698 Neighboring gene STARR-seq mESC enhancer starr_28699 Neighboring gene STARR-seq mESC enhancer starr_28700 Neighboring gene Egfr long non-coding downstream RNA Neighboring gene STARR-positive B cell enhancer ABC_E8386 Neighboring gene pleckstrin Neighboring gene STARR-positive B cell enhancer ABC_E1819 Neighboring gene signal peptide, CUB domain, EGF-like 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General protein information

Preferred Names
F-box only protein 48
Names
novel F-box domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359162.1NP_001346091.1  F-box only protein 48

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK037835, AK041978
    Consensus CDS
    CCDS24445.1
    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Related
    ENSMUSP00000105263.2, ENSMUST00000109635.2
    Conserved Domains (1) summary
    pfam12937
    Location:3877
    F-box-like
  2. NM_176982.2NP_795956.1  F-box only protein 48

    See identical proteins and their annotated locations for NP_795956.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK037835
    Consensus CDS
    CCDS24445.1
    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Related
    ENSMUSP00000057901.2, ENSMUST00000061327.2
    Conserved Domains (1) summary
    pfam12937
    Location:3877
    F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    16901225..16908516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514732.5XP_006514795.1  F-box only protein 48 isoform X1

    See identical proteins and their annotated locations for XP_006514795.1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:3877
    F-box-like
  2. XM_006514731.5XP_006514794.1  F-box only protein 48 isoform X1

    See identical proteins and their annotated locations for XP_006514794.1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:3877
    F-box-like
  3. XM_017314603.3XP_017170092.1  F-box only protein 48 isoform X1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:3877
    F-box-like
  4. XM_006514728.5XP_006514791.1  F-box only protein 48 isoform X1

    See identical proteins and their annotated locations for XP_006514791.1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:3877
    F-box-like
  5. XM_017314602.3XP_017170091.1  F-box only protein 48 isoform X1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:3877
    F-box-like
  6. XM_017314604.3XP_017170093.1  F-box only protein 48 isoform X1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:3877
    F-box-like
  7. XM_011243726.4XP_011242028.1  F-box only protein 48 isoform X1

    See identical proteins and their annotated locations for XP_011242028.1

    UniProtKB/Swiss-Prot
    Q8C9J8, Q8CAT8
    Conserved Domains (1) summary
    pfam12937
    Location:3877
    F-box-like