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Nt5dc1 5'-nucleotidase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 319638, updated on 30-Apr-2024

Summary

Official Symbol
Nt5dc1provided by MGI
Official Full Name
5'-nucleotidase domain containing 1provided by MGI
Primary source
MGI:MGI:2442446
See related
Ensembl:ENSMUSG00000039480 AllianceGenome:MGI:2442446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nt5c2l1; 6030401B09Rik
Summary
Predicted to enable 5'-nucleotidase activity. Orthologous to human NT5DC1 (5'-nucleotidase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.1), CNS E14 (RPKM 3.8) and 28 other tissues See more
Orthologs
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Genomic context

See Nt5dc1 in Genome Data Viewer
Location:
10 B1; 10 18.85 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (34179605..34294585, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (34303609..34418589, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26564 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:34001757-34001940 Neighboring gene STARR-positive B cell enhancer ABC_E3882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:34017128-34017331 Neighboring gene testis-specific protein, Y-encoded-like 1 Neighboring gene TSPY-like 4 Neighboring gene STARR-seq mESC enhancer starr_26275 Neighboring gene collagen, type X, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_26277 Neighboring gene fyn-related kinase Neighboring gene STARR-seq mESC enhancer starr_26278 Neighboring gene STARR-seq mESC enhancer starr_26279 Neighboring gene STARR-seq mESC enhancer starr_26280 Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107414

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
5'-nucleotidase domain-containing protein 1
Names
5'-nucleotidase, cytosolic II-like 1
cytosolic 5'-nucleotidase II-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347463.1NP_001334392.1  5'-nucleotidase domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning results in translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK049656, BB618670, BC098476
    UniProtKB/Swiss-Prot
    Q8C5P5
  2. NM_176968.5NP_795942.2  5'-nucleotidase domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_795942.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK145666, BB618670, BC098476
    Consensus CDS
    CCDS23779.1
    UniProtKB/Swiss-Prot
    Q3TAL3, Q3TPT8, Q3TTI3, Q3UL73, Q4G0D1, Q8C5P5
    UniProtKB/TrEMBL
    Q05AG7
    Related
    ENSMUSP00000047126.8, ENSMUST00000047885.14
    Conserved Domains (1) summary
    cl17687
    Location:11347
    5_nucleotid; 5' nucleotidase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    34179605..34294585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512764.4XP_006512827.1  5'-nucleotidase domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    E9QN01
    Related
    ENSMUSP00000097553.4, ENSMUST00000099973.4
    Conserved Domains (1) summary
    cl21460
    Location:7187
    HAD_like; Haloacid Dehalogenase-like Hydrolases