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Pdpr pyruvate dehydrogenase phosphatase regulatory subunit [ Mus musculus (house mouse) ]

Gene ID: 319518, updated on 18-Apr-2024

Summary

Official Symbol
Pdprprovided by MGI
Official Full Name
pyruvate dehydrogenase phosphatase regulatory subunitprovided by MGI
Primary source
MGI:MGI:2442188
See related
Ensembl:ENSMUSG00000033624 AllianceGenome:MGI:2442188
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1990; 4930402E16Rik
Summary
Predicted to enable oxidoreductase activity. Located in mitochondrion. Orthologous to human PDPR (pyruvate dehydrogenase phosphatase regulatory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 14.4), kidney adult (RPKM 8.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
8 E1; 8 57.95 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111821232..111866402)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111094609..111139781)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC) Neighboring gene C-type lectin domain family 18, member A Neighboring gene RIKEN cDNA 9430091E24 gene Neighboring gene golgi apparatus protein 1 Neighboring gene STARR-seq mESC enhancer starr_22692 Neighboring gene STARR-positive B cell enhancer ABC_E708 Neighboring gene predicted gene, 53455 Neighboring gene ring finger and WD repeat domain 3 Neighboring gene STARR-seq mESC enhancer starr_22693

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
NP_938050.1
XP_006531147.1
XP_030099464.1
XP_036009980.1
XP_036009981.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198308.1NP_938050.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_938050.1

    Status: PROVISIONAL

    Source sequence(s)
    AY223867
    Consensus CDS
    CCDS22670.1
    UniProtKB/Swiss-Prot
    Q6ZPF5, Q7TSQ8
    Related
    ENSMUSP00000046639.4, ENSMUST00000039333.10
    Conserved Domains (2) summary
    COG0404
    Location:452867
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:38425
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111821232..111866402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531084.5XP_006531147.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006531147.1

    UniProtKB/Swiss-Prot
    Q6ZPF5, Q7TSQ8
    Conserved Domains (2) summary
    COG0404
    Location:452867
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:38425
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  2. XM_036154087.1XP_036009980.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X2

    UniProtKB/TrEMBL
    D6RD07
    Related
    ENSMUSP00000121325.2, ENSMUST00000144377.2
    Conserved Domains (3) summary
    pfam01266
    Location:44384
    DAO; FAD dependent oxidoreductase
    pfam01571
    Location:462688
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam16350
    Location:405459
    FAO_M; FAD dependent oxidoreductase central domain
  3. XM_036154088.1XP_036009981.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X3

    Conserved Domains (2) summary
    COG0404
    Location:51466
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam16350
    Location:458
    FAO_M; FAD dependent oxidoreductase central domain
  4. XM_030243604.2XP_030099464.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X3

    Conserved Domains (2) summary
    COG0404
    Location:51466
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam16350
    Location:458
    FAO_M; FAD dependent oxidoreductase central domain