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Itga11 integrin alpha 11 [ Mus musculus (house mouse) ]

Gene ID: 319480, updated on 25-Nov-2021

Summary

Official Symbol
Itga11provided by MGI
Official Full Name
integrin alpha 11provided by MGI
Primary source
MGI:MGI:2442114
See related
Ensembl:ENSMUSG00000032243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732459H24Rik
Expression
Broad expression in limb E14.5 (RPKM 7.7), bladder adult (RPKM 6.3) and 18 other tissues See more
Orthologs
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Genomic context

See Itga11 in Genome Data Viewer
Location:
9; 9 B
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62585137..62691618)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62677855..62783979)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (62525662..62631786)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39353 Neighboring gene predicted gene, 53533 Neighboring gene dCTP pyrophosphatase 1 pseudogene Neighboring gene fem 1 homolog b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding involved in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
enables collagen receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in collagen-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within substrate-dependent cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in substrate-dependent cell migration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of integrin alpha11-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
integrin alpha-11
Names
integrin a11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176922.5NP_795896.4  integrin alpha-11 precursor

    See identical proteins and their annotated locations for NP_795896.4

    Status: VALIDATED

    Source sequence(s)
    AK028821, AY124460, BB731359, BB840351
    Consensus CDS
    CCDS23265.1
    UniProtKB/TrEMBL
    A0A0B4J1F0, Q7TQC3, Q8CE84
    Related
    ENSMUSP00000034774.9, ENSMUST00000034774.9
    Conserved Domains (3) summary
    smart00191
    Location:538592
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:163341
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:6351034
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    62585137..62691618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155048.1XP_036010941.1  integrin alpha-11 isoform X1

    Conserved Domains (3) summary
    smart00191
    Location:514568
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:139317
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:6111010
    Integrin_alpha2; Integrin alpha
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