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Cxxc4 CXXC finger 4 [ Mus musculus (house mouse) ]

Gene ID: 319478, updated on 7-May-2024

Summary

Official Symbol
Cxxc4provided by MGI
Official Full Name
CXXC finger 4provided by MGI
Primary source
MGI:MGI:2442112
See related
Ensembl:ENSMUSG00000044365 AllianceGenome:MGI:2442112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Idax; 9330210J02Rik; C030003J12Rik
Summary
Predicted to enable PDZ domain binding activity; methyl-CpG binding activity; and zinc ion binding activity. Acts upstream of or within Wnt signaling pathway. Located in cytoplasmic vesicle and nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; metanephros; nervous system; and nose. Orthologous to human CXXC4 (CXXC finger protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 3.9), CNS E18 (RPKM 3.3) and 7 other tissues See more
Orthologs
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Genomic context

See Cxxc4 in Genome Data Viewer
Location:
3 G3; 3 62.12 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (133938927..133967924)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (134236144..134262163)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54194 Neighboring gene predicted gene, 30648 Neighboring gene microRNA 1895 Neighboring gene peptidylprolyl isomerase A pseudogene 3_1390.1 Neighboring gene RIKEN cDNA 4930539C22 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90862

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CXXC-type zinc finger protein 4
Names
inhibition of the Dvl and axin complex protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004367.4NP_001004367.2  CXXC-type zinc finger protein 4

    Status: VALIDATED

    Source sequence(s)
    AC164408
    Consensus CDS
    CCDS17851.2
    UniProtKB/TrEMBL
    M0QWU0
    Related
    ENSMUSP00000138000.2, ENSMUST00000181904.3
    Conserved Domains (1) summary
    pfam02008
    Location:300340
    zf-CXXC; CXXC zinc finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    133938927..133967924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252642.2XP_030108502.1  CXXC-type zinc finger protein 4 isoform X2

    UniProtKB/TrEMBL
    M0QWU0
    Conserved Domains (1) summary
    pfam02008
    Location:300340
    zf-CXXC; CXXC zinc finger domain
  2. XM_006501561.4XP_006501624.1  CXXC-type zinc finger protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006501624.1

    Conserved Domains (1) summary
    pfam02008
    Location:300340
    zf-CXXC; CXXC zinc finger domain
  3. XM_006501568.4XP_006501631.1  CXXC-type zinc finger protein 4 isoform X3

    Conserved Domains (1) summary
    pfam02008
    Location:300340
    zf-CXXC; CXXC zinc finger domain
  4. XM_006501563.4XP_006501626.1  CXXC-type zinc finger protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006501626.1

    Conserved Domains (1) summary
    pfam02008
    Location:300340
    zf-CXXC; CXXC zinc finger domain
  5. XM_036163130.1XP_036019023.1  CXXC-type zinc finger protein 4 isoform X1

    Conserved Domains (1) summary
    pfam02008
    Location:300340
    zf-CXXC; CXXC zinc finger domain
  6. XM_006501566.5XP_006501629.1  CXXC-type zinc finger protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006501629.1

    Conserved Domains (1) summary
    pfam02008
    Location:300340
    zf-CXXC; CXXC zinc finger domain
  7. XM_006501564.4XP_006501627.1  CXXC-type zinc finger protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006501627.1

    Conserved Domains (1) summary
    pfam02008
    Location:300340
    zf-CXXC; CXXC zinc finger domain