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Fndc3a fibronectin type III domain containing 3A [ Mus musculus (house mouse) ]

Gene ID: 319448, updated on 12-May-2024

Summary

Official Symbol
Fndc3aprovided by MGI
Official Full Name
fibronectin type III domain containing 3Aprovided by MGI
Primary source
MGI:MGI:1196463
See related
Ensembl:ENSMUSG00000033487 AllianceGenome:MGI:1196463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sys; Fndc3; D14Ertd453e; 1700094E19Rik; F730017H24Rik
Summary
Acts upstream of or within several processes, including Sertoli cell development; fertilization; and spermatid development. Located in acrosomal vesicle; cytosol; and vesicle membrane. Is expressed in brain; inner ear; limb; and submandibular gland primordium. Orthologous to human FNDC3A (fibronectin type III domain containing 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 15.1), placenta adult (RPKM 12.9) and 28 other tissues See more
Orthologs
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Genomic context

See Fndc3a in Genome Data Viewer
Location:
14 D2; 14 37.62 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (72775388..72948141, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (72537948..72710701, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30500 Neighboring gene motilin receptor, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8898 Neighboring gene STARR-seq mESC enhancer starr_37102 Neighboring gene STARR-seq mESC enhancer starr_37103 Neighboring gene STARR-seq mESC enhancer starr_37104 Neighboring gene predicted gene, 35218 Neighboring gene STARR-seq mESC enhancer starr_37105 Neighboring gene predicted gene 4606 Neighboring gene predicted gene, 41206

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Phenotypes

Associated conditions

Description Tests
symplastic spermatids
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within Sertoli cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibronectin type-III domain-containing protein 3A
Names
fibronectin domain-containing protein 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207636.3NP_997519.2  fibronectin type-III domain-containing protein 3A

    See identical proteins and their annotated locations for NP_997519.2

    Status: VALIDATED

    Source sequence(s)
    AC158981, AC165423, CT010579
    Consensus CDS
    CCDS27264.1
    UniProtKB/Swiss-Prot
    Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
    UniProtKB/TrEMBL
    F6TLV3
    Related
    ENSMUSP00000086411.6, ENSMUST00000089017.12
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    72775388..72948141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519115.5XP_006519178.2  fibronectin type-III domain-containing protein 3A isoform X1

    See identical proteins and their annotated locations for XP_006519178.2

    UniProtKB/Swiss-Prot
    Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
    UniProtKB/TrEMBL
    F6TLV3
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_036158666.1XP_036014559.1  fibronectin type-III domain-containing protein 3A isoform X1

    UniProtKB/Swiss-Prot
    Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
    UniProtKB/TrEMBL
    F6TLV3
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_030247858.2XP_030103718.1  fibronectin type-III domain-containing protein 3A isoform X4

    UniProtKB/TrEMBL
    F6TLV3
    Conserved Domains (1) summary
    cd00063
    Location:307398
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_006519116.5XP_006519179.1  fibronectin type-III domain-containing protein 3A isoform X1

    See identical proteins and their annotated locations for XP_006519179.1

    UniProtKB/Swiss-Prot
    Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
    UniProtKB/TrEMBL
    F6TLV3
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. XM_030247857.2XP_030103717.1  fibronectin type-III domain-containing protein 3A isoform X1

    UniProtKB/Swiss-Prot
    Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
    UniProtKB/TrEMBL
    F6TLV3
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. XM_036158665.1XP_036014558.1  fibronectin type-III domain-containing protein 3A isoform X1

    UniProtKB/Swiss-Prot
    Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
    UniProtKB/TrEMBL
    F6TLV3
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  7. XM_017316055.3XP_017171544.1  fibronectin type-III domain-containing protein 3A isoform X2

    UniProtKB/TrEMBL
    F6TLV3
    Conserved Domains (1) summary
    cd00063
    Location:348439
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  8. XM_006519118.5XP_006519181.1  fibronectin type-III domain-containing protein 3A isoform X3

    UniProtKB/TrEMBL
    F6TLV3
    Related
    ENSMUSP00000124218.2, ENSMUST00000162825.8
    Conserved Domains (1) summary
    cd00063
    Location:315406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...