C5ar2 complement component 5a receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C5ar2provided by MGI
Official Full Name: complement component 5a receptor 2provided by MGI
Primary source: MGI:MGI:2442013
See related: Ensembl:ENSMUSG00000074361 AllianceGenome:MGI:2442013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C5L2; Gpr77; E030029A11Rik
Summary: Predicted to enable G protein-coupled receptor activity and complement component C5a receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; negative regulation of neutrophil chemotaxis; and regulation of cytokine production. Predicted to act upstream of or within signal transduction. Predicted to be located in apical part of cell and basal plasma membrane. Predicted to be active in plasma membrane. Orthologous to human C5AR2 (complement C5a receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 1.3), spleen adult (RPKM 1.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7; 7 A2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (15968512..15978079, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (16234587..16244154, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock.
Title: Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock.
The C5a/C5aR2 axis promotes renal inflammation and tissue damage.
Title: The C5a/C5aR2 axis promotes renal inflammation and tissue damage.
Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration.
Title: Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration.
Growth of B16.F0 melanoma tumors was increased in C5aR2-/- mice. Analysis of tumor-infiltrating leukocyte populations showed no significant differences between wild-type and C5aR2-/- mice.
Title: C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma.
C5aR2 transports tissue-derived C5a into the lumen of blood vessels to induce the initial arrest and adhesion of neutrophils, igniting a type III hypersensitivity reaction in the joint.
Title: Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation.
C5aR1 augment disease pathology and are interesting targets for treatment of meningococcal sepsis.
Title: Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections.
Taken together, this study shows distinct roles of C5aR1 and C5aR2 in a model of renal IRI with progressive renal fibrosis. Both C5aR1-/- and C5aR2-/- mouse strains, compared with WT mice, showed attenuated inflammation and fibrosis after IRI.
Title: Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury-induced inflammation and fibrosis.
in experimental renal fibrosis C5L2 and C5aR both contribute to tubular injury, and, while C5aR acts profibrotic, C5L2 does not play a role in extracellular matrix accumulation, arguing against C5L2 functioning simply as a decoy receptor
Title: Complement C5a receptors C5L2 and C5aR in renal fibrosis.
data demonstrate that complement-dependent and -independent mechanisms coexist in anti-Col17-autoantibody-mediated tissue destruction. C5aR1 and C5aR2 seem to play opposing roles in this process with C5aR1 exerting its primary effect in recruiting inflammatory cells to the skin during the early phase of the disease.
Title: Tissue Destruction in Bullous Pemphigoid Can Be Complement Independent and May Be Mitigated by C5aR2.
The role of C5aR2 in adaptive immunity.
Title: T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (T(REG)) Generation and T(REG)-Dependent Cardiac Allograft Survival.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

D7Msu2 (e-PCR), detects polymorphism
- UniSTS:239022

Homology

Homologs of the C5ar2 gene: The C5ar2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 185 organisms have orthologs with human gene C5ar2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables complement component C5a receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables complement receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: C5a anaphylatoxin chemotactic receptor 2

Names: C5a anaphylatoxin chemotactic receptor C5L2; G protein-coupled receptor 77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146005.2 → NP_001139477.2 C5a anaphylatoxin chemotactic receptor 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a distinct N-terminus but is the same length as isoform 1.

Source sequence(s)

AC156630

Consensus CDS

CCDS52036.2

UniProtKB/Swiss-Prot

Q3TVM8

Related

ENSMUSP00000158951.2, ENSMUST00000238927.2

Conserved Domains (1) summary

cd15114
Location:42 → 309

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_176912.5 → NP_795886.3 C5a anaphylatoxin chemotactic receptor 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.

Source sequence(s)

AC156630

Consensus CDS

CCDS52036.2

UniProtKB/Swiss-Prot

Q3TVM8

Related

ENSMUSP00000133056.3, ENSMUST00000171425.4

Conserved Domains (1) summary

cd15114
Location:42 → 309

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

15968512..15978079 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250594.2 → XP_011248896.1 C5a anaphylatoxin chemotactic receptor 2 isoform X3

Conserved Domains (1) summary

cd15114
Location:56 → 323

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006540053.4 → XP_006540116.1 C5a anaphylatoxin chemotactic receptor 2 isoform X4

See identical proteins and their annotated locations for XP_006540116.1

UniProtKB/Swiss-Prot

Q3TVM8, Q8BW93

Conserved Domains (1) summary

cd15114
Location:42 → 309

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006540052.4 → XP_006540115.1 C5a anaphylatoxin chemotactic receptor 2 isoform X4

See identical proteins and their annotated locations for XP_006540115.1

UniProtKB/Swiss-Prot

Q3TVM8, Q8BW93

Conserved Domains (1) summary

cd15114
Location:42 → 309

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006540055.5 → XP_006540118.1 C5a anaphylatoxin chemotactic receptor 2 isoform X4

See identical proteins and their annotated locations for XP_006540118.1

UniProtKB/Swiss-Prot

Q3TVM8, Q8BW93

Conserved Domains (1) summary

cd15114
Location:42 → 309

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006540054.5 → XP_006540117.1 C5a anaphylatoxin chemotactic receptor 2 isoform X4

See identical proteins and their annotated locations for XP_006540117.1

UniProtKB/Swiss-Prot

Q3TVM8, Q8BW93

Conserved Domains (1) summary

cd15114
Location:42 → 309

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006540049.2 → XP_006540112.2 C5a anaphylatoxin chemotactic receptor 2 isoform X4

See identical proteins and their annotated locations for XP_006540112.2

UniProtKB/Swiss-Prot

Q3TVM8, Q8BW93

Conserved Domains (1) summary

cd15114
Location:42 → 309

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036153163.1 → XP_036009056.1 C5a anaphylatoxin chemotactic receptor 2 isoform X2
XM_006540057.5 → XP_006540120.2 C5a anaphylatoxin chemotactic receptor 2 isoform X1

Conserved Domains (1) summary

cd15114
Location:79 → 346

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006540056.3 → XP_006540119.1 C5a anaphylatoxin chemotactic receptor 2 isoform X4

See identical proteins and their annotated locations for XP_006540119.1

UniProtKB/Swiss-Prot

Q3TVM8, Q8BW93

Conserved Domains (1) summary

cd15114
Location:42 → 309

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors