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C5ar2 complement component 5a receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 319430, updated on 24-Jan-2023

Summary

Official Symbol
C5ar2provided by MGI
Official Full Name
complement component 5a receptor 2provided by MGI
Primary source
MGI:MGI:2442013
See related
Ensembl:ENSMUSG00000074361 AllianceGenome:MGI:2442013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C5L2; Gpr77; E030029A11Rik
Summary
Predicted to enable G protein-coupled receptor activity and complement component C5a receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; negative regulation of neutrophil chemotaxis; and regulation of cytokine production. Predicted to act upstream of or within signal transduction. Predicted to be located in apical part of cell and basal plasma membrane. Predicted to be active in plasma membrane. Orthologous to human C5AR2 (complement C5a receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 1.3), spleen adult (RPKM 1.1) and 21 other tissues See more
Orthologs
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Genomic context

See C5ar2 in Genome Data Viewer
Location:
7; 7 A2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15968512..15978079, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16234587..16244154, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Meis homeobox 3 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 34 Neighboring gene predicted gene, 26473 Neighboring gene complement component 5a receptor 1 Neighboring gene InaF motif containing 1 Neighboring gene coiled-coil domain containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables complement component C5a receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables complement receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C5a anaphylatoxin chemotactic receptor 2
Names
C5a anaphylatoxin chemotactic receptor C5L2
G protein-coupled receptor 77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146005.2NP_001139477.2  C5a anaphylatoxin chemotactic receptor 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a distinct N-terminus but is the same length as isoform 1.
    Source sequence(s)
    AC156630
    Consensus CDS
    CCDS52036.2
    UniProtKB/Swiss-Prot
    Q3TVM8
    Related
    ENSMUSP00000158951.2, ENSMUST00000238927.2
    Conserved Domains (1) summary
    cd15114
    Location:42309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_176912.5NP_795886.3  C5a anaphylatoxin chemotactic receptor 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AC156630
    Consensus CDS
    CCDS52036.2
    UniProtKB/Swiss-Prot
    Q3TVM8
    Related
    ENSMUSP00000133056.3, ENSMUST00000171425.4
    Conserved Domains (1) summary
    cd15114
    Location:42309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    15968512..15978079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250594.2XP_011248896.1  C5a anaphylatoxin chemotactic receptor 2 isoform X3

    Conserved Domains (1) summary
    cd15114
    Location:56323
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_006540053.4XP_006540116.1  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    See identical proteins and their annotated locations for XP_006540116.1

    UniProtKB/Swiss-Prot
    Q3TVM8, Q8BW93
    Conserved Domains (1) summary
    cd15114
    Location:42309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_006540052.4XP_006540115.1  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    See identical proteins and their annotated locations for XP_006540115.1

    UniProtKB/Swiss-Prot
    Q3TVM8, Q8BW93
    Conserved Domains (1) summary
    cd15114
    Location:42309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_006540055.5XP_006540118.1  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    See identical proteins and their annotated locations for XP_006540118.1

    UniProtKB/Swiss-Prot
    Q3TVM8, Q8BW93
    Conserved Domains (1) summary
    cd15114
    Location:42309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_006540054.5XP_006540117.1  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    See identical proteins and their annotated locations for XP_006540117.1

    UniProtKB/Swiss-Prot
    Q3TVM8, Q8BW93
    Conserved Domains (1) summary
    cd15114
    Location:42309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_006540049.2XP_006540112.2  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    See identical proteins and their annotated locations for XP_006540112.2

    UniProtKB/Swiss-Prot
    Q3TVM8, Q8BW93
    Conserved Domains (1) summary
    cd15114
    Location:42309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. XM_036153163.1XP_036009056.1  C5a anaphylatoxin chemotactic receptor 2 isoform X2

  8. XM_006540057.5XP_006540120.2  C5a anaphylatoxin chemotactic receptor 2 isoform X1

    Conserved Domains (1) summary
    cd15114
    Location:79346
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  9. XM_006540056.3XP_006540119.1  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    See identical proteins and their annotated locations for XP_006540119.1

    UniProtKB/Swiss-Prot
    Q3TVM8, Q8BW93
    Conserved Domains (1) summary
    cd15114
    Location:42309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. XR_881730.4 RNA Sequence