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C5ar2 complement component 5a receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 319430, updated on 3-May-2025
Official Symbol
C5ar2provided by MGI
Official Full Name
complement component 5a receptor 2provided by MGI
Primary source
MGI:MGI:2442013
See related
Ensembl:ENSMUSG00000074361 AllianceGenome:MGI:2442013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C5L2; Gpr77; E030029A11Rik
Summary
Predicted to enable G protein-coupled receptor activity and complement component C5a receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; negative regulation of neutrophil chemotaxis; and regulation of cytokine production. Predicted to be located in apical part of cell and basal plasma membrane. Predicted to be active in plasma membrane. Orthologous to human C5AR2 (complement C5a receptor 2). [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in placenta adult (RPKM 1.3), spleen adult (RPKM 1.1) and 21 other tissues See more
Orthologs
human all
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See C5ar2 in Genome Data Viewer
Location:
7 A2; 7 8.77 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15968512..15978079, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16234587..16244154, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Meis homeobox 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16786573-16786682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16792577-16792686 Neighboring gene DExH-box helicase 34 Neighboring gene STARR-positive B cell enhancer ABC_E1334 Neighboring gene STARR-seq mESC enhancer starr_18126 Neighboring gene STARR-positive B cell enhancer ABC_E9684 Neighboring gene predicted gene, 26473 Neighboring gene complement component 5a receptor 1 Neighboring gene InaF motif containing 1 Neighboring gene coiled-coil domain containing 9

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. The ASP receptor C5L2 is regulated by metabolic hormones associated with insulin resistance. MacLaren R, et al. Biochem Cell Biol, 2007 Feb. PMID 17464341
  2. Reduced adipose tissue triglyceride synthesis and increased muscle fatty acid oxidation in C5L2 knockout mice. Paglialunga S, et al. J Endocrinol, 2007 Aug. PMID 17641279
  3. Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse. Karsten CM, et al. J Immunol, 2017 Nov 1. PMID 28864475
  4. The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury. Biggins PJC, et al. J Neurotrauma, 2017 Jun 15. PMID 28173736
  5. C5L2, the Second C5a Anaphylatoxin Receptor, Suppresses LPS-Induced Acute Lung Injury. Wang R, et al. Am J Respir Cell Mol Biol, 2016 Nov. PMID 27285858, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages.
    Title: C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages.
  2. The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita.
    Title: The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita.
  3. Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock.
    Title: Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock.
  4. The C5a/C5aR2 axis promotes renal inflammation and tissue damage.
    Title: The C5a/C5aR2 axis promotes renal inflammation and tissue damage.
  5. Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration.
    Title: Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration.
  6. Growth of B16.F0 melanoma tumors was increased in C5aR2-/- mice. Analysis of tumor-infiltrating leukocyte populations showed no significant differences between wild-type and C5aR2-/- mice.
    Title: C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma.
  7. C5aR2 transports tissue-derived C5a into the lumen of blood vessels to induce the initial arrest and adhesion of neutrophils, igniting a type III hypersensitivity reaction in the joint.
    Title: Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation.
  8. C5aR1 augment disease pathology and are interesting targets for treatment of meningococcal sepsis.
    Title: Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections.
  9. Taken together, this study shows distinct roles of C5aR1 and C5aR2 in a model of renal IRI with progressive renal fibrosis. Both C5aR1-/- and C5aR2-/- mouse strains, compared with WT mice, showed attenuated inflammation and fibrosis after IRI.
    Title: Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury-induced inflammation and fibrosis.
  10. in experimental renal fibrosis C5L2 and C5aR both contribute to tubular injury, and, while C5aR acts profibrotic, C5L2 does not play a role in extracellular matrix accumulation, arguing against C5L2 functioning simply as a decoy receptor
    Title: Complement C5a receptors C5L2 and C5aR in renal fibrosis.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (5)  1 citation

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables complement component C5a receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables complement receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in complement receptor mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of interleukin-8 production ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in apical part of cell ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
C5a anaphylatoxin chemotactic receptor 2
Names
C5a anaphylatoxin chemotactic receptor C5L2
G protein-coupled receptor 77

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146005.3 → NP_001139477.2  C5a anaphylatoxin chemotactic receptor 2

    Status: VALIDATED

    Source sequence(s)
    AC156630
    Consensus CDS
    CCDS52036.2
    UniProtKB/Swiss-Prot
    B2RQI1, Q3TVM8, Q8BW93
    UniProtKB/TrEMBL
    E9PVQ2, E9QQ21
    Related
    ENSMUSP00000158951.2, ENSMUST00000238927.2
    Conserved Domains (1) summary
    cd15114
    Location:42 → 309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001436147.1 → NP_001423076.1  C5a anaphylatoxin chemotactic receptor 2

    Status: VALIDATED

    Source sequence(s)
    AC156630
    UniProtKB/Swiss-Prot
    B2RQI1, Q3TVM8, Q8BW93
    UniProtKB/TrEMBL
    E9PVQ2, E9QQ21

  3. NM_001436148.1 → NP_001423077.1  C5a anaphylatoxin chemotactic receptor 2

    Status: VALIDATED

    Source sequence(s)
    AC156630
    UniProtKB/Swiss-Prot
    B2RQI1, Q3TVM8, Q8BW93
    UniProtKB/TrEMBL
    E9PVQ2, E9QQ21

  4. NM_001436149.1 → NP_001423078.1  C5a anaphylatoxin chemotactic receptor 2

    Status: VALIDATED

    Source sequence(s)
    AC156630
    UniProtKB/Swiss-Prot
    B2RQI1, Q3TVM8, Q8BW93
    UniProtKB/TrEMBL
    E9PVQ2, E9QQ21

  5. NM_001436150.1 → NP_001423079.1  C5a anaphylatoxin chemotactic receptor 2

    Status: VALIDATED

    Source sequence(s)
    AC156630
    UniProtKB/Swiss-Prot
    B2RQI1, Q3TVM8, Q8BW93
    UniProtKB/TrEMBL
    E9PVQ2, E9QQ21

  6. NM_176912.6 → NP_795886.3  C5a anaphylatoxin chemotactic receptor 2

    Status: VALIDATED

    Source sequence(s)
    AC156630
    Consensus CDS
    CCDS52036.2
    UniProtKB/Swiss-Prot
    B2RQI1, Q3TVM8, Q8BW93
    UniProtKB/TrEMBL
    E9PVQ2, E9QQ21
    Related
    ENSMUSP00000133056.3, ENSMUST00000171425.4
    Conserved Domains (1) summary
    cd15114
    Location:42 → 309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    15968512..15978079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250594.2 → XP_011248896.1  C5a anaphylatoxin chemotactic receptor 2 isoform X3

    UniProtKB/TrEMBL
    E9PVQ2
    Conserved Domains (1) summary
    cd15114
    Location:56 → 323
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006540053.4 → XP_006540116.1  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    See identical proteins and their annotated locations for XP_006540116.1

    UniProtKB/Swiss-Prot
    B2RQI1, Q3TVM8, Q8BW93
    UniProtKB/TrEMBL
    E9PVQ2, E9QQ21
    Conserved Domains (1) summary
    cd15114
    Location:42 → 309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_006540052.4 → XP_006540115.1  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    See identical proteins and their annotated locations for XP_006540115.1

    UniProtKB/Swiss-Prot
    B2RQI1, Q3TVM8, Q8BW93
    UniProtKB/TrEMBL
    E9PVQ2, E9QQ21
    Conserved Domains (1) summary
    cd15114
    Location:42 → 309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_006540055.5 → XP_006540118.1  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    Conserved Domains (1) summary
    cd15114
    Location:42 → 309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_006540054.5 → XP_006540117.1  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    Conserved Domains (1) summary
    cd15114
    Location:42 → 309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. XM_006540049.2 → XP_006540112.2  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    Conserved Domains (1) summary
    cd15114
    Location:42 → 309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  7. XM_036153163.1 → XP_036009056.1  C5a anaphylatoxin chemotactic receptor 2 isoform X2

    UniProtKB/TrEMBL
    E9PVQ2

  8. XM_006540057.5 → XP_006540120.2  C5a anaphylatoxin chemotactic receptor 2 isoform X1

    UniProtKB/TrEMBL
    E9QQ21
    Conserved Domains (1) summary
    cd15114
    Location:79 → 346
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  9. XM_006540056.3 → XP_006540119.1  C5a anaphylatoxin chemotactic receptor 2 isoform X4

    See identical proteins and their annotated locations for XP_006540119.1

    UniProtKB/Swiss-Prot
    B2RQI1, Q3TVM8, Q8BW93
    UniProtKB/TrEMBL
    E9PVQ2, E9QQ21
    Conserved Domains (1) summary
    cd15114
    Location:42 → 309
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. XR_881730.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BW93.1 GenPept UniProtKB/Swiss-Prot:Q8BW93

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