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Cht6 Chitinase 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31935, updated on 2-Nov-2024

Summary

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Official Symbol
Cht6provided by FlyBase
Official Full Name
Chitinase 6provided by FlyBase
Primary source
FLYBASE:FBgn0263132
Locus tag
Dmel_CG43374
See related
AllianceGenome:FB:FBgn0263132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15313; CG15314; CG2989; CG43374; Cht; cht6; CT5624; DmCht6; Dmel\CG43374
Old locus tag
Dmel_CG15313; Dmel_CG15314; Dmel_CG2989
Summary
Enables chitinase activity. Involved in chitin catabolic process; ecdysis, chitin-based cuticle; and regulation of tube size, open tracheal system. Predicted to be active in extracellular region. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Cht6 in Genome Data Viewer
Location:
9A4-9A5; 1-30 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10016845..10050803)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9910878..9944836)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene antisense RNA:CR45185 Neighboring gene antisense RNA:CR45601 Neighboring gene Yolk protein 2 Neighboring gene Yolk protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chitinase 6 is required for procuticle thickening and organ shape in Drosophila wing. Dong W, et al. Insect Sci, 2023 Apr. PMID 36114809
  2. Prenatal hyperbaric normoxia treatment improves healthspan and regulates chitin metabolic genes in Drosophila melanogaster. Yu S, et al. Aging (Albany NY), 2016 Oct 24. PMID 27777382, Free PMC Article
  3. Fluorescent Microscopy-Based Detection of Chitin in Intact Drosophila melanogaster. Flaven-Pouchon J, et al. Front Physiol, 2022. PMID 35557963, Free PMC Article
  4. Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens. Yue XZ, et al. Insect Sci, 2020 Aug. PMID 31240817
  5. Computational identification of novel chitinase-like proteins in the Drosophila melanogaster genome. Zhu Q, et al. Bioinformatics, 2004 Jan 22. PMID 14734306

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chitinase 6 is required for procuticle thickening and organ shape in Drosophila wing.
    Title: Chitinase 6 is required for procuticle thickening and organ shape in Drosophila wing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ecdysis, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube size, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chitinase 6
Names
CG43374-PC
CG43374-PF
CG43374-PG
CG43374-PH
CG43374-PI
CG43374-PJ
CG43374-PK
Cht6-PC
Cht6-PF
Cht6-PG
Cht6-PH
Cht6-PI
Cht6-PJ
Cht6-PK
NP_001096934.2
NP_001245598.1
NP_001245599.1
NP_001245600.1
NP_001245601.1
NP_001245602.1
NP_572598.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10016845..10050803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258673.2 → NP_001245602.1  chitinase 6, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245602.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NGY0
    Conserved Domains (4) summary
    cd02872
    Location:32 → 404
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:31 → 383
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:506 → 562
    CBM_14; Chitin binding Peritrophin-A domain
    cl00492
    Location:2691 → 2750
    Oxidored_q2; NADH-ubiquinone/plastoquinone oxidoreductase chain 4L

  2. NM_001258669.2 → NP_001245598.1  chitinase 6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245598.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDS9
    Conserved Domains (4) summary
    cd02872
    Location:32 → 404
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:31 → 383
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:506 → 562
    CBM_14; Chitin binding Peritrophin-A domain
    cl00492
    Location:2691 → 2750
    Oxidored_q2; NADH-ubiquinone/plastoquinone oxidoreductase chain 4L

  3. NM_001258671.2 → NP_001245600.1  chitinase 6, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245600.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEC2
    Conserved Domains (3) summary
    cd02872
    Location:32 → 404
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:31 → 383
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:506 → 562
    CBM_14; Chitin binding Peritrophin-A domain

  4. NM_001258670.2 → NP_001245599.1  chitinase 6, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245599.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NG70
    Conserved Domains (3) summary
    cd02872
    Location:32 → 404
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:31 → 383
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:506 → 562
    CBM_14; Chitin binding Peritrophin-A domain

  5. NM_132370.4 → NP_572598.3  chitinase 6, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572598.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2Z3
    Conserved Domains (4) summary
    cd02872
    Location:32 → 404
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:31 → 383
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:506 → 562
    CBM_14; Chitin binding Peritrophin-A domain
    cl00492
    Location:2691 → 2750
    Oxidored_q2; NADH-ubiquinone/plastoquinone oxidoreductase chain 4L

  6. NM_001258672.2 → NP_001245601.1  chitinase 6, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245601.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NF05
    Conserved Domains (3) summary
    cd02872
    Location:32 → 404
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:31 → 383
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:506 → 562
    CBM_14; Chitin binding Peritrophin-A domain

  7. NM_001103464.3 → NP_001096934.2  chitinase 6, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096934.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUP3
    Conserved Domains (3) summary
    cd02872
    Location:32 → 404
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:31 → 383
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:506 → 562
    CBM_14; Chitin binding Peritrophin-A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JUP3 A8JUP3
M9NDS9 M9NDS9
M9NEC2 M9NEC2
M9NF05 M9NF05
M9NG70 M9NG70
M9NGY0 M9NGY0
Q9W2Z3 Q9W2Z3

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