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Washc4 WASH complex subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 319277, updated on 15-Oct-2019

Summary

Official Symbol
Washc4provided by MGI
Official Full Name
WASH complex subunit 4provided by MGI
Primary source
MGI:MGI:2441787
See related
Ensembl:ENSMUSG00000034560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AA589518; Kiaa1033; mKIAA1033; A230046K03Rik
Expression
Broad expression in placenta adult (RPKM 6.5), CNS E11.5 (RPKM 5.1) and 24 other tissues See more
Orthologs

Genomic context

See Washc4 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
36
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (83543620..83596473)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (83006686..83059218)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene destrin pseudogene Neighboring gene uncharacterized LOC115487416 Neighboring gene aldehyde dehydrogenase 1 family, member L2 Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 Neighboring gene RIKEN cDNA 1500009L16 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosomal transport ISO
Inferred from Sequence Orthology
more info
 
endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome organization ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with BLOC-1 complex ISO
Inferred from Sequence Orthology
more info
 
WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
WASH complex ISO
Inferred from Sequence Orthology
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
WASH complex subunit 4
Names
WASH complex subunit 7
WASH complex subunit SWIP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033375.2NP_001028547.2  WASH complex subunit 4

    See identical proteins and their annotated locations for NP_001028547.2

    Status: VALIDATED

    Source sequence(s)
    AI605037, AK038582, AK161247, BQ561687
    Consensus CDS
    CCDS36015.1
    UniProtKB/Swiss-Prot
    Q3UMB9
    Related
    ENSMUSP00000039322.5, ENSMUST00000038388.6
    Conserved Domains (3) summary
    pfam14744
    Location:612945
    WASH-7_mid; WASH complex subunit 7
    pfam14745
    Location:32600
    WASH-7_N; WASH complex subunit 7, N-terminal
    pfam14746
    Location:9661135
    WASH-7_C; WASH complex subunit 7, C-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

    Range
    83543620..83596473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313963.2XP_017169452.1  WASH complex subunit 4 isoform X2

    Conserved Domains (3) summary
    pfam14744
    Location:424757
    WASH-7_mid; WASH complex subunit 7
    pfam14745
    Location:1412
    WASH-7_N; WASH complex subunit 7, N-terminal
    pfam14746
    Location:778947
    WASH-7_C; WASH complex subunit 7, C-terminal
  2. XM_030245113.1XP_030100973.1  WASH complex subunit 4 isoform X4

  3. XM_006513737.4XP_006513800.2  WASH complex subunit 4 isoform X1

    Conserved Domains (3) summary
    pfam14744
    Location:568901
    WASH-7_mid; WASH complex subunit 7
    pfam14745
    Location:8556
    WASH-7_N; WASH complex subunit 7, N-terminal
    pfam14746
    Location:9221091
    WASH-7_C; WASH complex subunit 7, C-terminal
  4. XM_006513738.4XP_006513801.1  WASH complex subunit 4 isoform X3

    Conserved Domains (3) summary
    pfam14744
    Location:485818
    WASH-7_mid; WASH complex subunit 7
    pfam14745
    Location:1473
    WASH-7_N; WASH complex subunit 7, N-terminal
    pfam14746
    Location:8391008
    WASH-7_C; WASH complex subunit 7, C-terminal
  5. XM_030245114.1XP_030100974.1  WASH complex subunit 4 isoform X4

  6. XM_006513739.3XP_006513802.1  WASH complex subunit 4 isoform X4

    Conserved Domains (3) summary
    pfam14744
    Location:200533
    WASH-7_mid; WASH complex subunit 7
    pfam14745
    Location:1188
    WASH-7_N; WASH complex subunit 7, N-terminal
    pfam14746
    Location:554723
    WASH-7_C; WASH complex subunit 7, C-terminal
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