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Npsr1 neuropeptide S receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 319239, updated on 8-Nov-2022

Summary

Official Symbol
Npsr1provided by MGI
Official Full Name
neuropeptide S receptor 1provided by MGI
Primary source
MGI:MGI:2441738
See related
Ensembl:ENSMUSG00000043659 AllianceGenome:MGI:2441738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPRA; MVTR; VRR1; PGR14; Gpr154; 9330128H10Rik
Summary
Predicted to enable neuropeptide receptor activity. Predicted to be involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of release of sequestered calcium ion into cytosol; and righting reflex. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in asthma; inflammatory bowel disease; newborn respiratory distress syndrome; and rheumatoid arthritis. Orthologous to human NPSR1 (neuropeptide S receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Npsr1 in Genome Data Viewer
Location:
9; 9 A3- A4
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (24009212..24229151)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (24097912..24317590)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene stromal membrane-associated protein 1 pseudogene Neighboring gene predicted gene, 22380 Neighboring gene dpy-19-like 1 (C. elegans) Neighboring gene uncharacterized LOC115487153

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables vasopressin receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuropeptide S receptor
Names
G protein-coupled receptor 154
G protein-coupled receptor PGR14
vasotocin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175678.3NP_783609.1  neuropeptide S receptor

    See identical proteins and their annotated locations for NP_783609.1

    Status: VALIDATED

    Source sequence(s)
    AK033957
    Consensus CDS
    CCDS22930.1
    UniProtKB/Swiss-Prot
    Q8BYA1, Q8BZP8
    UniProtKB/TrEMBL
    A1KXK3
    Related
    ENSMUSP00000056432.5, ENSMUST00000059650.11
    Conserved Domains (1) summary
    cd15197
    Location:50341
    7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    24009212..24229151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313417.3XP_017168906.1  neuropeptide S receptor isoform X1

    UniProtKB/Swiss-Prot
    Q8BYA1, Q8BZP8
    UniProtKB/TrEMBL
    A1KXK3
    Conserved Domains (1) summary
    cd15197
    Location:50341
    7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_036155047.1XP_036010940.1  neuropeptide S receptor isoform X1

    UniProtKB/Swiss-Prot
    Q8BYA1
    UniProtKB/TrEMBL
    A1KXK3
    Conserved Domains (1) summary
    cd15197
    Location:50341
    7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_017313418.2XP_017168907.1  neuropeptide S receptor isoform X2

    Related
    ENSMUSP00000115126.2, ENSMUST00000154644.2
    Conserved Domains (2) summary
    cd14964
    Location:930
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1188
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily