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Gpr4 G protein-coupled receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 319197, updated on 26-Sep-2022

Summary

Official Symbol
Gpr4provided by MGI
Official Full Name
G protein-coupled receptor 4provided by MGI
Primary source
MGI:MGI:2441992
See related
Ensembl:ENSMUSG00000044317 AllianceGenome:MGI:2441992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables G protein-coupled receptor activity. Involved in positive regulation of inflammatory response and regulation of vascular permeability. Acts upstream of or within several processes, including blood vessel development; negative regulation of angiogenesis; and response to acidic pH. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human GPR4 (G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 11.4), subcutaneous fat pad adult (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

See Gpr4 in Genome Data Viewer
Location:
7; 7 A3
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18946463..18958101)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19212538..19224176)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene echinoderm microtubule associated protein like 2 Neighboring gene microRNA 330 Neighboring gene VISTA enhancer mm1753 Neighboring gene optic atrophy 3 Neighboring gene predicted gene, 25134 Neighboring gene predicted gene, 38499

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis involved in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glomerular mesangial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to acidic pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G-protein coupled receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175668.4NP_783599.1  G-protein coupled receptor 4

    See identical proteins and their annotated locations for NP_783599.1

    Status: VALIDATED

    Source sequence(s)
    AC148988
    Consensus CDS
    CCDS20893.1
    UniProtKB/Swiss-Prot
    Q8BUD0
    Related
    ENSMUSP00000061243.5, ENSMUST00000060225.6
    Conserved Domains (2) summary
    pfam00001
    Location:37288
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:28145
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    18946463..18958101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)