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H2bc21 H2B clustered histone 21 [ Mus musculus (house mouse) ]

Gene ID: 319190, updated on 8-Jan-2023

Summary

Official Symbol
H2bc21provided by MGI
Official Full Name
H2B clustered histone 21provided by MGI
Primary source
MGI:MGI:2448415
See related
Ensembl:ENSMUSG00000068854 AllianceGenome:MGI:2448415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H2b-613; Hist2h2be
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of a putative stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2bc21 in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96128388..96131054)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96221072..96223738)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene H2A clustered histone 21 Neighboring gene H2A clustered histone 20 Neighboring gene H3 clustered histone 15 Neighboring gene H2A clustered histone 19

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CENP-A containing nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H2B type 2-E
Names
histone 2, H2be
histone cluster 2, H2be

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178214.5NP_835586.2  histone H2B type 2-E

    See identical proteins and their annotated locations for NP_835586.2

    Status: VALIDATED

    Source sequence(s)
    AC125099
    Consensus CDS
    CCDS17635.1
    UniProtKB/Swiss-Prot
    Q64524
    UniProtKB/TrEMBL
    A0A8C6GPC1
    Related
    ENSMUSP00000088287.7, ENSMUST00000090781.8
    Conserved Domains (1) summary
    smart00427
    Location:28124
    H2B; Histone H2B

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96128388..96131054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)