U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H2ac15 H2A clustered histone 15 [ Mus musculus (house mouse) ]

Gene ID: 319169, updated on 26-Sep-2022

Summary

Official Symbol
H2ac15provided by MGI
Official Full Name
H2A clustered histone 15provided by MGI
Primary source
MGI:MGI:2448297
See related
Ensembl:ENSMUSG00000063021 AllianceGenome:MGI:2448297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hist1h2ak
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See H2ac15 in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21937547..21938082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21753377..21753912, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 11 Neighboring gene H4 clustered histone 12 Neighboring gene H2B clustered histone 15 Neighboring gene predicted gene 11274

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone H2A type 1-K
Names
histone 1, H2ak
histone cluster 1, H2ak

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178183.2NP_835490.1  histone H2A type 1-K

    See identical proteins and their annotated locations for NP_835490.1

    Status: REVIEWED

    Source sequence(s)
    AL589651
    Consensus CDS
    CCDS26293.1
    UniProtKB/Swiss-Prot
    Q0VE75, Q8CGP7
    Related
    ENSMUSP00000074310.3, ENSMUST00000074752.4
    Conserved Domains (2) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional
    cd00074
    Location:6120
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    21937547..21938082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)