U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H2ac8 H2A clustered histone 8 [ Mus musculus (house mouse) ]

Gene ID: 319166, updated on 24-Jan-2023

Summary

Official Symbol
H2ac8provided by MGI
Official Full Name
H2A clustered histone 8provided by MGI
Primary source
MGI:MGI:2448290
See related
Ensembl:ENSMUSG00000069272 AllianceGenome:MGI:2448290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hist1h2ae; 1190022L06
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See H2ac8 in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23754837..23755394, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23570663..23571220, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H1.3 linker histone, cluster member Neighboring gene H3 clustered histone 6 Neighboring gene H2B clustered histone 8 Neighboring gene H2B clustered histone 7

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CENP-A containing nucleosome ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H2A type 1-E
Names
Histone H2A type 1-E
histone 1, H2ae
histone H2A type 1
histone cluster 1, H2ae

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178187.4NP_835494.1  histone H2A type 1-E

    See identical proteins and their annotated locations for NP_835494.1

    Status: REVIEWED

    Source sequence(s)
    AL592149
    Consensus CDS
    CCDS26348.1
    UniProtKB/Swiss-Prot
    C0HKE1, C0HKE2, C0HKE3, C0HKE4, C0HKE5, C0HKE6, C0HKE7, C0HKE8, C0HKE9, Q5SZZ2
    UniProtKB/TrEMBL
    A0A6P5QP89, A0A8C6G9K1, B2RVF0
    Related
    ENSMUSP00000100034.4, ENSMUST00000102969.6
    Conserved Domains (1) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23754837..23755394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)