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TTC6 tetratricopeptide repeat domain 6 [ Homo sapiens (human) ]

Gene ID: 319089, updated on 7-Apr-2024

Summary

Official Symbol
TTC6provided by HGNC
Official Full Name
tetratricopeptide repeat domain 6provided by HGNC
Primary source
HGNC:HGNC:19739
See related
Ensembl:ENSG00000139865 AllianceGenome:HGNC:19739
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf25; NCRNA00291
Expression
Biased expression in prostate (RPKM 2.5), testis (RPKM 2.0) and 3 other tissues See more
Orthologs
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Genomic context

Location:
14q21.1
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (37595629..37842717)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (31784758..32031773)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (38064834..38311922)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene mirror-image polydactyly 1 Neighboring gene FOXA motif-containing MPRA enhancer 271 Neighboring gene RNA, U6 small nuclear 886, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2445 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:38057104-38057944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:38060408-38060957 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:38064763-38065962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:38069061-38069730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:38068389-38069060 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:38124049-38125248 Neighboring gene forkhead box A1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:38255187-38255688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:38255689-38256188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:38304329-38304828 Neighboring gene RNA, U6 small nuclear 1277, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5683 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:38363413-38364243 Neighboring gene long intergenic non-protein coding RNA 517 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:38463923-38464596 Neighboring gene uncharacterized LOC105370456 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:38473631-38474167

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
tetratricopeptide repeat protein 6
Names
TPR repeat protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310135.5NP_001297064.2  tetratricopeptide repeat protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121790, AL136296, AL163151
    Consensus CDS
    CCDS91870.1
    UniProtKB/TrEMBL
    G3V3A5
    Related
    ENSP00000451131.1, ENST00000553443.6
    Conserved Domains (4) summary
    smart00028
    Location:18161849
    TPR; Tetratricopeptide repeats
    COG5010
    Location:18311879
    TadD; Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]
    TIGR02917
    Location:9241808
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:17501776
    TPR; TPR repeat [structural motif]
  2. NM_001368142.2NP_001355071.1  tetratricopeptide repeat protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL136296, AL163151
    Consensus CDS
    CCDS91871.1
    UniProtKB/Swiss-Prot
    Q3SY88, Q86TZ1, Q96CE6
    Related
    ENSP00000417788.1, ENST00000476979.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    37595629..37842717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021254.2XP_016876743.1  tetratricopeptide repeat protein 6 isoform X2

  2. XM_017021255.2XP_016876744.1  tetratricopeptide repeat protein 6 isoform X3

  3. XM_047431335.1XP_047287291.1  tetratricopeptide repeat protein 6 isoform X5

  4. XM_047431337.1XP_047287293.1  tetratricopeptide repeat protein 6 isoform X9

  5. XM_011537432.3XP_011535734.1  tetratricopeptide repeat protein 6 isoform X7

    See identical proteins and their annotated locations for XP_011535734.1

    Conserved Domains (3) summary
    COG0457
    Location:8881153
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:10691096
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:933964
    TPR_1; Tetratricopeptide repeat
  6. XM_017021257.2XP_016876746.1  tetratricopeptide repeat protein 6 isoform X10

  7. XM_047431332.1XP_047287288.1  tetratricopeptide repeat protein 6 isoform X1

  8. XM_047431333.1XP_047287289.1  tetratricopeptide repeat protein 6 isoform X1

  9. XM_047431334.1XP_047287290.1  tetratricopeptide repeat protein 6 isoform X4

  10. XM_017021256.2XP_016876745.1  tetratricopeptide repeat protein 6 isoform X4

  11. XM_011537431.3XP_011535733.1  tetratricopeptide repeat protein 6 isoform X6

    Conserved Domains (5) summary
    smart00028
    Location:12531286
    TPR; Tetratricopeptide repeats
    TIGR02917
    Location:3531245
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:11871213
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:346377
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:12531317
    TPR_11; TPR repeat
  12. XM_047431336.1XP_047287292.1  tetratricopeptide repeat protein 6 isoform X8

RNA

  1. XR_007064009.1 RNA Sequence

  2. XR_001750287.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    31784758..32031773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375963.1XP_054231938.1  tetratricopeptide repeat protein 6 isoform X2

  2. XM_054375965.1XP_054231940.1  tetratricopeptide repeat protein 6 isoform X3

  3. XM_054375968.1XP_054231943.1  tetratricopeptide repeat protein 6 isoform X5

  4. XM_054375972.1XP_054231947.1  tetratricopeptide repeat protein 6 isoform X9

  5. XM_054375970.1XP_054231945.1  tetratricopeptide repeat protein 6 isoform X7

  6. XM_054375973.1XP_054231948.1  tetratricopeptide repeat protein 6 isoform X10

  7. XM_054375964.1XP_054231939.1  tetratricopeptide repeat protein 6 isoform X1

  8. XM_054375962.1XP_054231937.1  tetratricopeptide repeat protein 6 isoform X1

  9. XM_054375967.1XP_054231942.1  tetratricopeptide repeat protein 6 isoform X4

  10. XM_054375966.1XP_054231941.1  tetratricopeptide repeat protein 6 isoform X4

  11. XM_054375969.1XP_054231944.1  tetratricopeptide repeat protein 6 isoform X6

  12. XM_054375971.1XP_054231946.1  tetratricopeptide repeat protein 6 isoform X8

RNA

  1. XR_008488860.1 RNA Sequence

  2. XR_008488861.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007795.1: Suppressed sequence

    Description
    NM_001007795.1: This RefSeq was permanently suppressed because the CDS was partial.