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TTC6 tetratricopeptide repeat domain 6 [ Homo sapiens (human) ]

Gene ID: 319089, updated on 23-Nov-2021

Summary

Official Symbol
TTC6provided by HGNC
Official Full Name
tetratricopeptide repeat domain 6provided by HGNC
Primary source
HGNC:HGNC:19739
See related
Ensembl:ENSG00000139865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf25; NCRNA00291
Expression
Biased expression in prostate (RPKM 2.5), testis (RPKM 2.0) and 3 other tissues See more
Orthologs
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Genomic context

See TTC6 in Genome Data Viewer
Location:
14q21.1
Exon count:
41
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (37593159..37842717)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (38064834..38311922)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene mirror-image polydactyly 1 Neighboring gene FOXA motif-containing MPRA enhancer 271 Neighboring gene RNA, U6 small nuclear 886, pseudogene Neighboring gene forkhead box A1 Neighboring gene RNA, U6 small nuclear 1277, pseudogene Neighboring gene long intergenic non-protein coding RNA 517 Neighboring gene uncharacterized LOC105370456

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119358, MGC119360, MGC119361

General protein information

Preferred Names
tetratricopeptide repeat protein 6
Names
TPR repeat protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310135.5NP_001297064.2  tetratricopeptide repeat protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121790, AL136296, AL163151
    Related
    ENSP00000451131.1, ENST00000553443.5
    Conserved Domains (4) summary
    smart00028
    Location:18161849
    TPR; Tetratricopeptide repeats
    COG5010
    Location:18311879
    TadD; Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]
    TIGR02917
    Location:9241808
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:17501776
    TPR; TPR repeat [structural motif]
  2. NM_001368142.2NP_001355071.1  tetratricopeptide repeat protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL136296, AL163151
    Related
    ENSP00000417788.1, ENST00000476979.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    37593159..37842717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449560.1XP_024305328.1  tetratricopeptide repeat protein 6 isoform X1

    Conserved Domains (3) summary
    smart00028
    Location:18401873
    TPR; Tetratricopeptide repeats
    sd00006
    Location:17741800
    TPR; TPR repeat [structural motif]
    cl26002
    Location:9401832
    TPR_11; TPR repeat
  2. XM_017021254.1XP_016876743.1  tetratricopeptide repeat protein 6 isoform X2

  3. XM_017021255.1XP_016876744.1  tetratricopeptide repeat protein 6 isoform X3

  4. XM_011537432.2XP_011535734.1  tetratricopeptide repeat protein 6 isoform X7

    See identical proteins and their annotated locations for XP_011535734.1

    Conserved Domains (3) summary
    COG0457
    Location:8881153
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:10691096
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:933964
    TPR_1; Tetratricopeptide repeat
  5. XM_017021257.1XP_016876746.1  tetratricopeptide repeat protein 6 isoform X8

  6. XM_017021256.1XP_016876745.1  tetratricopeptide repeat protein 6 isoform X4

  7. XM_011537430.2XP_011535732.1  tetratricopeptide repeat protein 6 isoform X5

    Conserved Domains (5) summary
    smart00028
    Location:13591392
    TPR; Tetratricopeptide repeats
    TIGR02917
    Location:4591351
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:12931319
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:452483
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:13591423
    TPR_11; TPR repeat
  8. XM_011537431.2XP_011535733.1  tetratricopeptide repeat protein 6 isoform X6

    Conserved Domains (5) summary
    smart00028
    Location:12531286
    TPR; Tetratricopeptide repeats
    TIGR02917
    Location:3531245
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:11871213
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:346377
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:12531317
    TPR_11; TPR repeat

RNA

  1. XR_943762.2 RNA Sequence

  2. XR_001750287.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007795.1: Suppressed sequence

    Description
    NM_001007795.1: This RefSeq was permanently suppressed because the CDS was partial.
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