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HNRNPK heterogeneous nuclear ribonucleoprotein K [ Homo sapiens (human) ]

Gene ID: 3190, updated on 13-Jan-2020

Summary

Official Symbol
HNRNPKprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Kprovided by HGNC
Primary source
HGNC:HGNC:5044
See related
Ensembl:ENSG00000165119 MIM:600712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AUKS; CSBP; TUNP; HNRPK
Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 179.3), lymph node (RPKM 145.8) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPK in Genome Data Viewer
Location:
9q21.32
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (83968083..83980782, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (86582998..86595692, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene kinesin family member 27 Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene chromosome 9 open reading frame 64 Neighboring gene microRNA 7-1 Neighboring gene RecQ mediated genome instability 1 Neighboring gene uncharacterized LOC101927575 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 33 Neighboring gene uncharacterized LOC105376116 Neighboring gene solute carrier family 28 member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
AU-KLINE SYNDROME
MedGen: C4225274 OMIM: 616580 GeneReviews: Au-Kline Syndrome
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2016-08-11)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2016-08-11)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein K (HNRNPK, TUNP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein K (HNRNPK, TUNP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein K (HNRNPK, TUNP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
nef The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation PubMed
nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase. The proline-rich domain (amino-acids 289-315) of hnRNP-K is required for the recruitment of activated LCK PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein K (HNRNPK, TUNP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacts with the heterogeneous nuclear ribonucleoproteins (hnRNP) K. The amino acids 9-14 in Rev are required for the interaction between Rev and hnRNP K PubMed
rev hnRNP K forms a complex with Sam68 and HIV-1 RRE RNA and inhibits Sam68-mediated, RRE-dependent gene expression suggesting a possible interaction with Rev PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41122

Gene Ontology Provided by GOA

Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
podosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein K
Names
dC-stretch binding protein
transformation upregulated nuclear protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029577.1 RefSeqGene

    Range
    4873..17572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318186.1NP_001305115.1  heterogeneous nuclear ribonucleoprotein K isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks an alternate in-frame exon in the coding region and uses an alternate acceptor splice site at the last coding exon compared to transcript variant 1. It encodes isoform c, which is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB209562, AK300744, AL354733, BU736090, DC318847
    UniProtKB/Swiss-Prot
    P61978
    UniProtKB/TrEMBL
    B4DUQ1
    Related
    ENSP00000409456.1, ENST00000457156.5
    Conserved Domains (3) summary
    cd00105
    Location:365428
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122186
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
  2. NM_001318187.1NP_001305116.1  heterogeneous nuclear ribonucleoprotein K isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to transcript variant 1. It encodes isoform d, which is shorter than isoform a.
    Source sequence(s)
    AB209562, AL354733, BU736090, DC318847
    UniProtKB/Swiss-Prot
    P61978
    Conserved Domains (3) summary
    cd00105
    Location:365428
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122186
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
  3. NM_001318188.1NP_001305117.1  heterogeneous nuclear ribonucleoprotein K isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate acceptor splice site at the last coding exon compared to transcript variant 1. This results in a frame-shift and an isoform (b) with a distinct C-terminus compared to isoform a. Transcript variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AB209562, BC025321, BU736090, DC318847
    Consensus CDS
    CCDS6667.1
    UniProtKB/Swiss-Prot
    P61978
    Related
    ENSP00000353552.5, ENST00000360384.9
    Conserved Domains (3) summary
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
  4. NM_002140.4NP_002131.2  heterogeneous nuclear ribonucleoprotein K isoform a

    See identical proteins and their annotated locations for NP_002131.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Transcript variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AB209562, BC000355, BU736090, DC428989
    Consensus CDS
    CCDS6668.1
    UniProtKB/Swiss-Prot
    P61978
    Related
    ENSP00000365458.4, ENST00000376281.8
    Conserved Domains (3) summary
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
  5. NM_031262.3NP_112552.1  heterogeneous nuclear ribonucleoprotein K isoform b

    See identical proteins and their annotated locations for NP_112552.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site at the last coding exon compared to transcript variant 1. This results in a frame-shift and an isoform (b) with a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB209562, BC014980, BU736090, DC428989
    Consensus CDS
    CCDS6667.1
    UniProtKB/Swiss-Prot
    P61978
    Conserved Domains (3) summary
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
  6. NM_031263.4NP_112553.1  heterogeneous nuclear ribonucleoprotein K isoform a

    See identical proteins and their annotated locations for NP_112553.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to transcript variant 1. Transcript variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AB209562, BC000355, BU736090, DC318847
    Consensus CDS
    CCDS6668.1
    UniProtKB/Swiss-Prot
    P61978
    Related
    ENSP00000365439.3, ENST00000376263.8
    Conserved Domains (3) summary
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    83968083..83980782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518616.2XP_011516918.1  heterogeneous nuclear ribonucleoprotein K isoform X4

    See identical proteins and their annotated locations for XP_011516918.1

    UniProtKB/TrEMBL
    B4DUQ1
    Conserved Domains (3) summary
    cd00105
    Location:365428
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122186
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
  2. XM_017014668.1XP_016870157.1  heterogeneous nuclear ribonucleoprotein K isoform X2

    UniProtKB/Swiss-Prot
    P61978
    Related
    ENSP00000317788.4, ENST00000351839.7
    Conserved Domains (3) summary
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
  3. XM_005251960.2XP_005252017.1  heterogeneous nuclear ribonucleoprotein K isoform X1

    See identical proteins and their annotated locations for XP_005252017.1

    UniProtKB/Swiss-Prot
    P61978
    Conserved Domains (3) summary
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
  4. XM_017014669.1XP_016870158.1  heterogeneous nuclear ribonucleoprotein K isoform X4

    UniProtKB/TrEMBL
    B4DUQ1
    Conserved Domains (3) summary
    cd00105
    Location:365428
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122186
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
  5. XM_005251963.4XP_005252020.1  heterogeneous nuclear ribonucleoprotein K isoform X3

    See identical proteins and their annotated locations for XP_005252020.1

    UniProtKB/Swiss-Prot
    P61978
    Conserved Domains (3) summary
    cd00105
    Location:365428
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122186
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
  6. XM_005251965.3XP_005252022.1  heterogeneous nuclear ribonucleoprotein K isoform X3

    See identical proteins and their annotated locations for XP_005252022.1

    UniProtKB/Swiss-Prot
    P61978
    Conserved Domains (3) summary
    cd00105
    Location:365428
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122186
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:1343
    ROKNT; ROKNT (NUC014) domain
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