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CG31674 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318878, updated on 5-Jul-2025
Official Symbol
CG31674provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0051674
Locus tag
Dmel_CG31674
See related
AllianceGenome:FB:FBgn0051674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9332; Dmel\CG31674
Summary
Predicted to enable glyoxylate reductase (NADPH) activity and hydroxypyruvate reductase (NADH) activity. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CG31674 in Genome Data Viewer
Location:
38F1-38F1; 2-54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20831262..20832859)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20831262..20832859)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Outer segment 5 Neighboring gene Serpin 38F Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44307

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Transporters and tubule crystals in the insect Malpighian tubule. Reynolds CJ, et al. Curr Opin Insect Sci, 2021 Oct. PMID 34044181, Free PMC Article
  2. Kukoamine A alleviates nephrolithiasis by inhibiting endogenous oxalate synthesis via the IL-6/JAK/STAT3/DAO signaling pathway. Ju Y, et al. Phytomedicine, 2024 Dec. PMID 39461201
  3. Proteomic Analysis of Red Ginseng on Prolonging the Life Span of Male Drosophila melanogaster. Hou W, et al. Front Pharmacol, 2021. PMID 34177563, Free PMC Article
  4. A genome-wide RNAi screen reveals multiple regulators of caspase activation. Yi CH, et al. J Cell Biol, 2007 Nov 19. PMID 17998402, Free PMC Article
  5. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Borrás T, et al. Genetics, 2003 Feb. PMID 12618402, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glyoxylate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxypyruvate reductase (NADH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
uncharacterized protein
Names
CG31674-PA
CG31674-PB
NP_001286111.1
NP_610063.4

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20831262..20832859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136219.6 → NP_610063.4  uncharacterized protein Dmel_CG31674, isoform A

    See identical proteins and their annotated locations for NP_610063.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWS3, Q8INU6
    Related
    FBpp0080952
    Conserved Domains (2) summary
    COG1052
    Location:9 → 321
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:8 → 319
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  2. NM_001299182.1 → NP_001286111.1  uncharacterized protein Dmel_CG31674, isoform B

    See identical proteins and their annotated locations for NP_001286111.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWS3, Q8INU6
    Conserved Domains (2) summary
    COG1052
    Location:9 → 321
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:8 → 319
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AWS3 Q6AWS3
Q8INU6 Q8INU6

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