His3:CG31613 histone H3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: His3:CG31613provided by FlyBase
Official Full Name: histone H3provided by FlyBase
Primary source: FLYBASE:FBgn0051613
Locus tag: Dmel_CG31613
See related: AllianceGenome:FB:FBgn0051613
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG31613; Dmel\CG31613; His3
Summary: Predicted to enable nucleosomal DNA binding activity. Predicted to be involved in nucleosome assembly. Located in chromatin and polytene chromosome. Part of RCAF complex. Is expressed in spermatozoon. Orthologous to human H3C13 (H3 clustered histone 13); H3C14 (H3 clustered histone 14); and H3C15 (H3 clustered histone 15). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

Location:: 39D3-39D3; 2-54 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (21425193..21425721)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (21425193..21425721)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Total H3-Dendra2 in the nucleus decreases with each cleavage cycle. This change in nuclear composition is due to depletion of large pools (>50%) of free protein that are present in the early cycles. The per nucleus import rate halves with each cycle and construct a mathematical model in which increasing histone demand determines the dynamics of nuclear H3 supply.
Title: Dynamics of Free and Chromatin-Bound Histone H3 during Early Embryogenesis.
Acetylation of histone H3 lysine 23 is localized to promoters and correlates with endogenous ecdysone induced gene activation.
Title: Ecdysone induced gene expression is associated with acetylation of histone H3 lysine 23 in Drosophila melanogaster.
structural, energetic, and mutational analyses of the complex between the Drosophila HP1 chromodomain and the histone H3 tail with a methyllysine at residue 9, a modification associated with epigenetic silencing, are presented
Title: Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail.
Phosphorylation of H3 is linked to transcription and can be modulated by the structure of the promoter.
Title: Phosphorylation of histone H3 during transcriptional activation depends on promoter structure.
In Su(var)3-9 null mutants, H3-K9 methylation at chromocentre heterochromatin is strongly reduced, indicating that SU(VAR)3-9 is the major heterochromatin-specific HMTase in Drosophila.
Title: Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.
Mutants in protein phosphatase type 2A (PP2A) also display reduced genome-wide H3 dephosphorylation, and sites of H3 phosphorylation that do not contain heat shock genes remain transcriptionally active during heat shock in PP2A mutants.
Title: Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster.
these studies establish a link between histone methylation and Polycomb group-mediated gene silencing
Title: Role of histone H3 lysine 27 methylation in Polycomb-group silencing.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables nucleosomal DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nucleosome assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RCAF complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info