GluRIIE Glutamate receptor IIE [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GluRIIEprovided by FlyBase
Official Full Name: Glutamate receptor IIEprovided by FlyBase
Primary source: FLYBASE:FBgn0051201
Locus tag: Dmel_CG31201
See related: AllianceGenome:FB:FBgn0051201
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG31201; DmelGluRIIE; Dmel\CG31201; GluR-IIE
Summary: Enables glutamate-gated calcium ion channel activity. Involved in calcium ion transport and neuromuscular synaptic transmission. Located in muscle cell postsynaptic specialization. Part of ionotropic glutamate receptor complex. Is expressed in abdominal ventral muscle cell; embryonic/larval hypodermal muscle cell; larval somatic muscle cell; and somatic muscle primordium. Human ortholog(s) of this gene implicated in Huntington's disease; autosomal recessive intellectual developmental disorder 6; childhood absence epilepsy; and chronic obstructive pulmonary disease. Orthologous to several human genes including GRIK1 (glutamate ionotropic receptor kainate type subunit 1); GRIK2 (glutamate ionotropic receptor kainate type subunit 2); and GRIK3 (glutamate ionotropic receptor kainate type subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: 92F4-92F4; 3-69 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20644154..20648716, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16469876..16474438, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-gated calcium ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	IC Inferred by Curator more info	PubMed
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, glutamatergic	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of ionotropic glutamate receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in muscle cell postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate receptor IIE

Names: CG31201-PB; GluRIIE-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

20644154..20648716 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001043268.2 → NP_001036733.1 glutamate receptor IIE

See identical proteins and their annotated locations for NP_001036733.1

Status: REVIEWED

UniProtKB/TrEMBL

B8A433, Q0KI42, Q5U165

Conserved Domains (4) summary

cd06382
Location:42 → 396

PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors

cd13714
Location:419 → 790

PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily

pfam00060
Location:551 → 824

Lig_chan; Ligand-gated ion channel

pfam01094
Location:51 → 382

ANF_receptor; Receptor family ligand binding region