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HNRNPAB heterogeneous nuclear ribonucleoprotein A/B [ Homo sapiens (human) ]

Gene ID: 3182, updated on 21-Dec-2019

Summary

Official Symbol
HNRNPABprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein A/Bprovided by HGNC
Primary source
HGNC:HGNC:5034
See related
Ensembl:ENSG00000197451 MIM:602688
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABBP1; HNRPAB
Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 79.0), appendix (RPKM 50.6) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPAB in Genome Data Viewer
Location:
5q35.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (178204533..178211163)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177631508..177638184)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NAD(P)HX epimerase pseudogene Neighboring gene germ cell-less 2, spermatogenesis associated Neighboring gene uncharacterized LOC112267937 Neighboring gene 5-phosphohydroxy-L-lysine phospho-lyase Neighboring gene collagen type XXIII alpha 1 chain Neighboring gene mitochondrial ribosomal protein L50 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPAB is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40338

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
sequence-specific double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein A/B
Names
ABBP-1
APOBEC1-binding protein 1
apobec-1 binding protein 1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1-binding protein 1
hnRNP A/B
hnRNP type A/B protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004499.4NP_004490.2  heterogeneous nuclear ribonucleoprotein A/B isoform b

    See identical proteins and their annotated locations for NP_004490.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter, compared to isoform a.
    Source sequence(s)
    AK097657, BC001616, BC004561
    Consensus CDS
    CCDS34310.1
    UniProtKB/Swiss-Prot
    Q99729
    Related
    ENSP00000348093.5, ENST00000355836.9
    Conserved Domains (3) summary
    cd12584
    Location:150229
    RRM2_hnRNPAB; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    cd12757
    Location:71145
    RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    pfam08143
    Location:170
    CBFNT; CBFNT (NUC161) domain
  2. NM_031266.3NP_112556.2  heterogeneous nuclear ribonucleoprotein A/B isoform a

    See identical proteins and their annotated locations for NP_112556.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the full length isoform (a).
    Source sequence(s)
    AK097657, BC001616
    Consensus CDS
    CCDS34309.1
    UniProtKB/Swiss-Prot
    Q99729
    Related
    ENSP00000351108.3, ENST00000358344.8
    Conserved Domains (3) summary
    cd12584
    Location:150229
    RRM2_hnRNPAB; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    cd12757
    Location:71145
    RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    pfam08143
    Location:170
    CBFNT; CBFNT (NUC161) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    178204533..178211163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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