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HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Homo sapiens (human) ]

Gene ID: 3181, updated on 13-Jan-2019

Summary

Official Symbol
HNRNPA2B1provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein A2/B1provided by HGNC
Primary source
HGNC:HGNC:5033
See related
Ensembl:ENSG00000122566 MIM:600124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNPA2; HNRPA2; HNRPB1; SNRPB1; HNRNPA2; HNRNPB1; IBMPFD2; HNRPA2B1
Summary
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 202.7), appendix (RPKM 193.9) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPA2B1 in Genome Data Viewer
Location:
7p15.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (26189920..26200793, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (26229547..26240413, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375199 Neighboring gene uncharacterized LOC105375198 Neighboring gene nuclear factor, erythroid 2 like 3 Neighboring gene chromobox 3 Neighboring gene ribosomal protein L23 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
env Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
Envelope surface glycoprotein gp160, precursor env Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with HNRNPA2B1 is increased by RRE PubMed
Tat tat Expression of HIV-1 Tat downregulates the abundance of heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) in the nucleoli of Jurkat T-cells PubMed
Vif vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed
vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G12-1: AGGGA) to regulate the levels of vif mRNA and Vif protein expression PubMed
Vpr vpr Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies translation regulatory and RNA binding proteins eIF3h, eEF1A-1, and hnRNPA2 as IN-binding partners PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) at amino acid residues 135-136 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22720, DKFZp779B0244

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-rich strand telomeric DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
N6-methyladenosine-containing RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
pre-mRNA intronic binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G-quadruplex DNA unwinding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA metabolic process TAS
Traceable Author Statement
more info
 
RNA transport IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
miRNA transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomerase RNA reverse transcriptase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of telomere maintenance via telomere lengthening ISS
Inferred from Sequence or Structural Similarity
more info
 
primary miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Cajal body ISS
Inferred from Sequence or Structural Similarity
more info
 
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoproteins A2/B1
Names
HNRNPA2B1/MYC fusion
epididymis secretory sperm binding protein
hnRNP A2 / hnRNP B1
nuclear ribonucleoprotein particle A2 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029680.1 RefSeqGene

    Range
    5001..15858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002137.3NP_002128.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2

    See identical proteins and their annotated locations for NP_002128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A2) lacks 36 bases at the beginning of the coding region compared to variant B1. The N-terminus of isoform A2 is thus different from isoform B1. This isoform (A2) is the predominant protein.
    Source sequence(s)
    AC004520, DB244417, M29065
    Consensus CDS
    CCDS5397.1
    UniProtKB/Swiss-Prot
    P22626
    Related
    ENSP00000349101.7, ENST00000356674.7
    Conserved Domains (3) summary
    cd12581
    Location:100179
    RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:787
    RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    pfam11627
    Location:290311
    HnRNPA1; Nuclear factor hnRNPA1
  2. NM_031243.2NP_112533.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform B1

    See identical proteins and their annotated locations for NP_112533.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B1) contains an additional 36 bases compared to variant A2. This additional region affects only the beginning of the coding region. The N-terminus of isoform B1 is thus different from isoform A2.
    Source sequence(s)
    AC004520, DB244417, M29064
    Consensus CDS
    CCDS43557.1
    UniProtKB/Swiss-Prot
    P22626
    Related
    ENSP00000346694.4, ENST00000354667.8
    Conserved Domains (3) summary
    cd12581
    Location:112191
    RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:1999
    RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    pfam11627
    Location:302323
    HnRNPA1; Nuclear factor hnRNPA1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    26189920..26200793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012109.2XP_016867598.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

    UniProtKB/Swiss-Prot
    P22626
    Conserved Domains (3) summary
    cd12581
    Location:100179
    RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:787
    RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    pfam11627
    Location:290311
    HnRNPA1; Nuclear factor hnRNPA1
  2. XM_005249729.1XP_005249786.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

    See identical proteins and their annotated locations for XP_005249786.1

    UniProtKB/Swiss-Prot
    P22626
    Related
    ENSP00000354021.4, ENST00000360787.8
    Conserved Domains (3) summary
    cd12581
    Location:112191
    RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:1999
    RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    pfam11627
    Location:302323
    HnRNPA1; Nuclear factor hnRNPA1
  3. XM_017012110.2XP_016867599.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

    UniProtKB/Swiss-Prot
    P22626
    Related
    ENSP00000497298.1, ENST00000608362.2
    Conserved Domains (3) summary
    cd12581
    Location:100179
    RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:787
    RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    pfam11627
    Location:290311
    HnRNPA1; Nuclear factor hnRNPA1

RNA

  1. XR_242077.2 RNA Sequence

  2. XR_001744666.2 RNA Sequence

  3. XR_001744673.2 RNA Sequence

  4. XR_001744674.2 RNA Sequence

  5. XR_002956424.1 RNA Sequence

  6. XR_001744675.1 RNA Sequence

  7. XR_242076.1 RNA Sequence

  8. XR_428077.1 RNA Sequence

  9. XR_001744665.1 RNA Sequence

  10. XR_002956425.1 RNA Sequence

  11. XR_001744671.2 RNA Sequence

  12. XR_001744672.2 RNA Sequence

  13. XR_001744670.2 RNA Sequence

  14. XR_001744663.1 RNA Sequence

  15. XR_001744664.1 RNA Sequence

  16. XR_001744662.1 RNA Sequence

  17. XR_001744668.2 RNA Sequence

  18. XR_001744667.2 RNA Sequence

  19. XR_001744669.2 RNA Sequence

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