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ldd lipid droplet defective [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318066, updated on 8-Feb-2025

Summary

Official Symbol
lddprovided by FlyBase
Official Full Name
lipid droplet defectiveprovided by FlyBase
Primary source
FLYBASE:FBgn0083956
Locus tag
Dmel_CG34120
See related
AllianceGenome:FB:FBgn0083956
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT04622; CG1819; CG32516; CG34120; DmCG1819; Dmel\CG34120
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 4A; and autosomal recessive congenital ichthyosis 4B. Orthologous to human ABCA12 (ATP binding cassette subfamily A member 12). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See ldd in Genome Data Viewer
Location:
19F1-19F1; 1-65 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21123634..21140951)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20994661..21011978)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene stargazin-like protein Neighboring gene antisense RNA:CR44374 Neighboring gene uncoordinated Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

mobile_element

  • Loc: 21125511-21125869 mobile_element_type = transposon:INE-1{}6026
  • Loc: 21130319-21130694 mobile_element_type = transposon:INE-1{}6028
  • Loc: 21132964-21133122 mobile_element_type = transposon:INE-1{}6029

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
lipid droplet defective
Names
CG34120-PB
CG34120-PC
CG34120-PD
CG34120-PE
ldd-PB
ldd-PC
ldd-PD
ldd-PE
NP_001036286.1
NP_001036287.1
NP_001138224.1
NP_001285513.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    21123634..21140951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298584.1NP_001285513.1  lipid droplet defective, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285513.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BHW4, X2JG15
    Conserved Domains (4) summary
    TIGR01188
    Location:16661945
    drrA; daunorubicin resistance ABC transporter ATP-binding subunit
    cd03263
    Location:16511857
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    pfam12698
    Location:12301601
    ABC2_membrane_3; ABC-2 family transporter protein
    cl22894
    Location:14361552
    Mem_trans; Membrane transport protein
  2. NM_001042822.4NP_001036287.1  lipid droplet defective, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036287.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHQ2, Q5BHW4
    Conserved Domains (5) summary
    TIGR01188
    Location:16651944
    drrA; daunorubicin resistance ABC transporter ATP-binding subunit
    cd03263
    Location:16501856
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    pfam12698
    Location:12291600
    ABC2_membrane_3; ABC-2 family transporter protein
    cl14023
    Location:13711472
    DUF4400; Domain of unknown function (DUF4400)
    cl22894
    Location:14351551
    Mem_trans; Membrane transport protein
  3. NM_001144752.2NP_001138224.1  lipid droplet defective, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138224.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QD66, Q5BHW4
    Conserved Domains (5) summary
    TIGR01188
    Location:16491928
    drrA; daunorubicin resistance ABC transporter ATP-binding subunit
    cd03263
    Location:16341840
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    pfam12698
    Location:12131584
    ABC2_membrane_3; ABC-2 family transporter protein
    cl14023
    Location:13551456
    DUF4400; Domain of unknown function (DUF4400)
    cl22894
    Location:14191535
    Mem_trans; Membrane transport protein
  4. NM_001042821.2NP_001036286.1  lipid droplet defective, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036286.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQ38, Q8MZF6
    Conserved Domains (1) summary
    TIGR01257
    Location:885
    rim_protein; retinal-specific rim ABC transporter