Ogg1 8-oxoguanine DNA glycosylase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ogg1provided by FlyBase
Official Full Name: 8-oxoguanine DNA glycosylaseprovided by FlyBase
Primary source: FLYBASE:FBgn0027864
Locus tag: Dmel_CG1795
See related: AllianceGenome:FB:FBgn0027864
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1795; BcDNA:LD19945; CG1795; Dmel\CG1795; dOgg1; dOGG1; OGG1
Summary: Enables DNA N-glycosylase activity and class I DNA-(apurinic or apyrimidinic site) endonuclease activity. Involved in base-excision repair and cellular response to oxidative stress. Predicted to be located in mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 8A2-8A2; 1-24 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8690327..8691811)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8584360..8585844)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dOgg1 and RpS3 in mitochondria increase cell survival after exposure to the nitric oxide donor SNAP
Title: Effects of ectopic expression of Drosophila DNA glycosylases dOgg1 and RpS3 in mitochondria.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables oxidized purine nucleobase lesion DNA N-glycosylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in base-excision repair	IDA Inferred from Direct Assay more info	PubMed
involved_in base-excision repair	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in base-excision repair, AP site formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 8-oxoguanine DNA glycosylase

Names: CG1795-PA; Ogg1-PA

NP_572499.2

EC 3.2.2.23

EC 4.2.99.18

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8690327..8691811

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132271.5 → NP_572499.2 8-oxoguanine DNA glycosylase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572499.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3I8

UniProtKB/TrEMBL

C4IXZ6, Q6NL83

Related

FBpp0071168

Conserved Domains (3) summary

TIGR00588
Location:33 → 324

ogg; 8-oxoguanine DNA-glycosylase (ogg)

cd00056
Location:137 → 318

ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases

pfam07934
Location:26 → 140

OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain