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mthl14 methuselah-like 14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318046, updated on 6-Jul-2026
Official Symbol
mthl14provided by FlyBase
Official Full Name
methuselah-like 14provided by FlyBase
Primary source
FLYBASE:FBgn0052476
Locus tag
Dmel_CG32476
See related
AllianceGenome:FB:FBgn0052476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE31310; CG32476; Dmel\CG32476; Mthl14
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Is expressed in adult head; embryonic/larval foregut; and embryonic/larval midgut. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See mthl14 in Genome Data Viewer
Location:
61B3-61B3; 3-1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (247491..250305)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (247491..250305)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Enhancer of bithorax Neighboring gene DISCO Interacting Protein 2 Neighboring gene ncRNA Neighboring gene Tudor staphylococcal nuclease Neighboring gene wee Augmin

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Methuselah proteins in Drosophila: Structural and evolutionary insights from mathematical genomics. Hassan SS, et al. Biochem Biophys Res Commun, 2025 Sep 1. PMID 40570637
  2. Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster. Englund C, et al. Dev Genes Evol, 2006 Jan. PMID 16220264
  3. Massive parallel expansions of Methuselah/Methuselah-like receptors in schizophoran Diptera. Friedrich M, et al. J Exp Zool B Mol Dev Evol, 2018 Sep. PMID 30058118
  4. Gene Ages, Nomenclatures, and Functional Diversification of the Methuselah/Methuselah-Like GPCR Family in Drosophila and Tribolium. Friedrich M, et al. J Exp Zool B Mol Dev Evol, 2016 Dec. PMID 28074535
  5. Methuselah/Methuselah-like G protein-coupled receptors constitute an ancient metazoan gene family. de Mendoza A, et al. Sci Rep, 2016 Feb 26. PMID 26915348, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
methuselah-like 14
Names
CG32476-PA
mthl14-PA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    247491..250305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167821.3 → NP_728509.1  methuselah-like 14

    See identical proteins and their annotated locations for NP_728509.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SYV9
    Related
    FBpp0072402
    Conserved Domains (1) summary
    cd15039
    Location:239 → 512
    7tmB3_Methuselah-like; Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYV9.1 Q8SYV9

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