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CG32409 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318016, updated on 9-Mar-2023

Summary

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Official Symbol
CG32409provided by FlyBase
Primary source
FLYBASE:FBgn0052409
Locus tag
Dmel_CG32409
See related
AllianceGenome:FB:FBgn0052409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD24586; Dmel\CG32409
Summary
Predicted to be involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal large subunit biogenesis; and ribosomal large subunit export from nucleus. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm anlage; embryonic Malpighian tubule; embryonic/larval muscle system; gastrula embryo; and germ layer derivative. Orthologous to human RRS1 (ribosome biogenesis regulator 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CG32409 in Genome Data Viewer
Location:
64F4-64F4; 3-15 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5899528..5900936)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5892628..5894036)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon subunit 2 Neighboring gene uncharacterized protein Neighboring gene Glutaminyl cyclase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Relating past and present diet to phenotypic and transcriptomic variation in the fruit fly. May CM, et al. BMC Genomics, 2017 Aug 22. PMID 28830340, Free PMC Article
  2. C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Moens TG, et al. Acta Neuropathol, 2019 Mar. PMID 30604225, Free PMC Article
  3. Identification of pathways regulating cell size and cell-cycle progression by RNAi. Björklund M, et al. Nature, 2006 Feb 23. PMID 16496002
  4. An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling. Vinayagam A, et al. Cell Rep, 2016 Sep 13. PMID 27626673, Free PMC Article
  5. The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation. Cugusi S, et al. Mol Cell Proteomics, 2015 Jun. PMID 25776889, Free PMC Article

See all (31) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Homologs of the CG32409 gene: The CG32409 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
  • Orthologs

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG32409-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5899528..5900936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168144.3 → NP_729108.2  uncharacterized protein Dmel_CG32409 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729108.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I937
    Related
    FBpp0076738, FBtr0077030
    Conserved Domains (1) summary
    pfam04939
    Location:31 → 190
    RRS1; Ribosome biogenesis regulatory protein (RRS1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U108 Q5U108
Q8I937 Q8I937
Q8MR24 Q8MR24

Gene LinkOut

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