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sphinx1 sphinx1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318005, updated on 6-Jul-2026
Official Symbol
sphinx1provided by FlyBase
Official Full Name
sphinx1provided by FlyBase
Primary source
FLYBASE:FBgn0052383
Locus tag
Dmel_CG32383
See related
AllianceGenome:FB:FBgn0052383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32383; CG8555; Dmel\CG32383; SPH194; SPH194a; sphinx-1; Sphinx-1; Sphinx1; Spx1
Summary
Involved in Toll receptor ligand protein activation cascade; defense response to other organism; and sexual reproduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See sphinx1 in Genome Data Viewer
Location:
66A1-66A1; 3-21 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7438421..7439405, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7431521..7432505, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rac2 Neighboring gene uncharacterized protein Neighboring gene sphinx2 Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Evolutionary rate patterns of genes involved in the Drosophila Toll and Imd signaling pathway. Han M, et al. BMC Evol Biol, 2013 Nov 8. PMID 24209511, Free PMC Article
  2. Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation. Kambris Z, et al. Curr Biol, 2006 Apr 18. PMID 16631589
  3. The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes. Williams AM, et al. Genome Biol Evol, 2023 Mar 3. PMID 36911982, Free PMC Article
  4. The Drosophila Toll signaling pathway. Valanne S, et al. J Immunol, 2011 Jan 15. PMID 21209287
  5. Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila. Wong A, et al. Mol Biol Evol, 2012 Jan. PMID 21940639, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables serine-type endopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in Toll receptor ligand protein activation cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mating IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IC
Inferred by Curator
more info
 PubMed 
Preferred Names
sphinx1
Names
CG32383-PB
sphinx1-PB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7438421..7439405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168214.2 → NP_729255.2  sphinx1

    See identical proteins and their annotated locations for NP_729255.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V3R6, Q8IQ79
    Conserved Domains (2) summary
    smart00020
    Location:25 → 245
    Tryp_SPc; Trypsin-like serine protease
    cl21584
    Location:26 → 248
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQ79 Q8IQ79

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