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DDX51 DEAD-box helicase 51 [ Homo sapiens (human) ]

Gene ID: 317781, updated on 7-Aug-2022

Summary

Official Symbol
DDX51provided by HGNC
Official Full Name
DEAD-box helicase 51provided by HGNC
Primary source
HGNC:HGNC:20082
See related
Ensembl:ENSG00000185163 AllianceGenome:HGNC:20082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 5.1), ovary (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

See DDX51 in Genome Data Viewer
Location:
12q24.33
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132136594..132144319, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (132186137..132193862, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (132621139..132628864, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene E1A binding protein p400 Neighboring gene small nucleolar RNA, H/ACA box 49 Neighboring gene EP400 pseudogene 1 Neighboring gene uncharacterized LOC107987169 Neighboring gene nucleolar complex associated 4 homolog Neighboring gene long intergenic non-protein coding RNA 2361

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC42193, DKFZp686N2081

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ATP-dependent RNA helicase DDX51
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DEAD box protein 51
NP_778236.2
XP_011536558.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175066.4NP_778236.2  ATP-dependent RNA helicase DDX51

    See identical proteins and their annotated locations for NP_778236.2

    Status: VALIDATED

    Source sequence(s)
    AC138466, AK097078, BC029279, BC040185, BC063603
    Consensus CDS
    CCDS41865.1
    UniProtKB/Swiss-Prot
    Q8N8A6, Q96ED1
    Related
    ENSP00000380495.3, ENST00000397333.4
    Conserved Domains (4) summary
    PRK01297
    Location:109609
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    pfam00271
    Location:489600
    Helicase_C; Helicase conserved C-terminal domain
    pfam15724
    Location:79159
    TMEM119; TMEM119 family
    cl21455
    Location:205449
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    132136594..132144319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538256.2XP_011536558.1  ATP-dependent RNA helicase DDX51 isoform X1

    Conserved Domains (3) summary
    smart00487
    Location:213455
    DEXDc; DEAD-like helicases superfamily
    pfam15724
    Location:79159
    TMEM119; TMEM119 family
    cl21455
    Location:205449
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160007.1 Reference GRCh38.p14 PATCHES

    Range
    43623..51348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    132186137..132193862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)